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Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies.
Greco, Beatrice; Malacarne, Valeria; De Girardi, Federica; Scotti, Giulia Maria; Manfredi, Francesco; Angelino, Elia; Sirini, Camilla; Camisa, Barbara; Falcone, Laura; Moresco, Marta Angiola; Paolella, Katia; Di Bono, Mattia; Norata, Rossana; Sanvito, Francesca; Arcangeli, Silvia; Doglioni, Claudio; Ciceri, Fabio; Bonini, Chiara; Graziani, Andrea; Bondanza, Attilio; Casucci, Monica.
Afiliación
  • Greco B; Innovative Immunotherapies Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Malacarne V; Vita-Salute San Raffaele University, 20132 Milan, Italy.
  • De Girardi F; Lipid Signaling in Cancer and Metabolism Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Scotti GM; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, 10124 Torino, Italy.
  • Manfredi F; Innovative Immunotherapies Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Angelino E; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Sirini C; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Camisa B; Lipid Signaling in Cancer and Metabolism Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Falcone L; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, 10124 Torino, Italy.
  • Moresco MA; Innovative Immunotherapies Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Paolella K; Vita-Salute San Raffaele University, 20132 Milan, Italy.
  • Di Bono M; Innovative Immunotherapies Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Norata R; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Sanvito F; Innovative Immunotherapies Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Arcangeli S; Innovative Immunotherapies Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Doglioni C; Innovative Immunotherapies Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Ciceri F; Innovative Immunotherapies Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Bonini C; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Graziani A; San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Bondanza A; Pathology Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Casucci M; Innovative Immunotherapies Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Sci Transl Med ; 14(628): eabg3072, 2022 01 19.
Article en En | MEDLINE | ID: mdl-35044789
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Receptores Quiméricos de Antígenos Límite: Animals / Female / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Receptores Quiméricos de Antígenos Límite: Animals / Female / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos