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CSF1 receptor inhibition of tenosynovial giant cell tumor using novel disease-specific MRI measures of tumor burden.
Peterfy, Charles; Chen, Yan; Countryman, Peter; Chmielowski, Bartosz; Anthony, Stephen P; Healey, John H; Wainberg, Zev A; Cohn, Allen L; Shapiro, Geoffrey I; Keedy, Vicki L; Singh, Arun; Puzanov, Igor; Wagner, Andrew J; Qian, Meng; Sterba, Mike; Hsu, Henry H; Tong-Starksen, Sandra; Tap, William D.
Afiliación
  • Peterfy C; Spire Sciences, Inc., Boca Raton, FL, USA.
  • Chen Y; Spire Sciences, Inc., Boca Raton, FL, USA.
  • Countryman P; Spire Sciences, Inc., Boca Raton, FL, USA.
  • Chmielowski B; University of California Los Angeles, Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA.
  • Anthony SP; Evergreen Hematology & Oncology, Spokane, WA 99218, USA.
  • Healey JH; Memorial Sloan Kettering Cancer Center & Weill Cornell Medical College, New York, NY 10065, USA.
  • Wainberg ZA; UCLA Medical Center, Santa Monica, CA 90404, USA.
  • Cohn AL; Rocky Mountain Cancer Centers, Denver, CO 80216, USA.
  • Shapiro GI; Dana-Farber Cancer Institute & Harvard Medical School, Boston, MA 02215, USA.
  • Keedy VL; Vanderbilt University Medical Center, Nashville, TN 37235, USA.
  • Singh A; UCLA Medical Center, Santa Monica, CA 90404, USA.
  • Puzanov I; Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
  • Wagner AJ; Dana-Farber Cancer Institute & Harvard Medical School, Boston, MA 02215, USA.
  • Qian M; Daiichi Sankyo, Inc., Basking Ridge, NJ 07920, USA.
  • Sterba M; Plexxikon Inc., South San Francisco, CA 94080, USA.
  • Hsu HH; Plexxikon Inc., South San Francisco, CA 94080, USA.
  • Tong-Starksen S; Plexxikon Inc., South San Francisco, CA 94080, USA.
  • Tap WD; Memorial Sloan Kettering Cancer Center & Weill Cornell Medical College, New York, NY 10065, USA.
Future Oncol ; 18(12): 1449-1459, 2022 Apr.
Article en En | MEDLINE | ID: mdl-35040698
Aim: Monitoring treatment of tenosynovial giant cell tumor (TGCT) is complicated by the irregular shape and asymmetrical growth of the tumor. We compared responses to pexidartinib by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 with those by tumor volume score (TVS) and modified RECIST (m-RECIST). Materials & methods: MRIs acquired every two cycles were assessed centrally using RECIST 1.1, m-RECIST and TVS and tissue damage score (TDS). Results: Thirty-one evaluable TGCT patients were treated with pexidartinib. From baseline to last visit, 94% of patients (29/31) showed a decrease in tumor size (median change: -60% [RECIST], -66% [m-RECIST], -79% [TVS]). All methods showed 100% disease control rate. For TDS, improvements were seen in bone erosion (32%), bone marrow edema (58%) and knee effusion (46%). Conclusion: TVS and m-RECIST offer potentially superior alternatives to conventional RECIST for monitoring disease progression and treatment response in TGCT. TDS adds important information about joint damage associated with TGCT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptor de Factor Estimulante de Colonias de Macrófagos / Receptores de Factor Estimulante de Colonias de Granulocitos y Macrófagos / Tumor de Células Gigantes de las Vainas Tendinosas Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Future Oncol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptor de Factor Estimulante de Colonias de Macrófagos / Receptores de Factor Estimulante de Colonias de Granulocitos y Macrófagos / Tumor de Células Gigantes de las Vainas Tendinosas Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Future Oncol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido