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Broadband Dielectric Spectroscopic Analysis toward Characterization of the Hydration State and Bioprotective Superiority of Trehalose.
Hu, Junru; Liao, Zhiqiang; Yano, Yasuo; Yamahara, Hiroyasu; Tabata, Hitoshi.
Afiliación
  • Hu J; Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Liao Z; Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Yano Y; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Yamahara H; Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
  • Tabata H; Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
J Phys Chem B ; 126(3): 708-715, 2022 01 27.
Article en En | MEDLINE | ID: mdl-35040322
Alteration of the hydrogen-bond (H-bond) network by trehalose is acknowledged as a bioprotective agent. However, most studies exploring the hydration superiority of the trehalose structure are limited structure are limited by the computational cost or a narrow-range spectrum. In the present study, the structural and dynamical behaviors of the H-bond network of trehalose and maltose solutions were observed and compared with a broadband dielectric spectrum (100 MHz-18 THz) to investigate the influence of the trehalose structure on the bioprotective function. From the relaxation time, the reorientation cooperativity, resonant frequency, and damping constant of water-water vibration, the symmetric structure of trehalose allowed a more significant H-bond strengthening effect and homogeneous aqueous environment. In contrast, the difference in the hydration number between trehalose and maltose was negligible. Thus, the enhanced H-bond strengthening effect and homogeneous aqueous environment owing to the symmetric structure are the essential factors that contribute to the remarkable bioprotective effect of trehalose.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trehalosa / Agua Idioma: En Revista: J Phys Chem B Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trehalosa / Agua Idioma: En Revista: J Phys Chem B Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos