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Anti-plasmodial, Cytotoxic and Antioxidant Activities of Selected Ghanaian Medicinal Plants.
Appiah-Opong, Regina; Agyemang, Kojo; Dotse, Eunice; Atchoglo, Philip; Owusu, Kofi Baffour-Awuah; Aning, Abigail; Sakyiamah, Maxwell; Adegle, Richard; Ayertey, Frederick; Appiah, Alfred Ampomah; Nyarko, Alexander K.
Afiliación
  • Appiah-Opong R; 118922Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Agyemang K; 118922Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Dotse E; 118922Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Atchoglo P; 118922Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Owusu KB; 118922Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Aning A; 118922Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Sakyiamah M; Centre for Plant Medicine Research, Mampong-Akuapim, Ghana.
  • Adegle R; Centre for Plant Medicine Research, Mampong-Akuapim, Ghana.
  • Ayertey F; Centre for Plant Medicine Research, Mampong-Akuapim, Ghana.
  • Appiah AA; Centre for Plant Medicine Research, Mampong-Akuapim, Ghana.
  • Nyarko AK; University of Ghana School of Pharmacy, College of Health Sciences, 58835University of Ghana, Accra, Ghana.
J Evid Based Integr Med ; 27: 2515690X211073709, 2022.
Article en En | MEDLINE | ID: mdl-35037519
Malaria affects about half of the world's population. The sub-Saharan African region is the most affected. Plant natural products have been a major source of antimalarial drugs; the first (quinine) and present (artemisinin) antimalarials are of natural product origin. Some secondary metabolites demonstrate adjuvant antioxidant effects and selective activity. The focus of this study was to investigate the anti-plasmodial activity, cytotoxicities and antioxidant properties of eight (8) Ghanaian medicinal plants. The anti-plasmodial activity was determined using the SYBR green assay and the tetrazolium-based colorimetric assay (MTT) was employed to assess cytotoxicity of extracts to human RBCs and HL-60 cells. Antioxidant potential of plant extracts was evaluated using Folin-Ciocalteu and superoxide dismutase assays. Phytochemical contstituents of the plant extracts were also assessed. All the extracts demonstrated anti-plasmodial activities at concentrations <50 µg/ml. Parkia clappertoniana and Terminalia ivorensis elicited the strongest anti-plasmodial activities with 50% inhibitory concentrations (IC50) of 1.13 µg/ml and 0.95 µg/ml, respectively. This is the first report on anti-plasmodial activities of Baphia nitida, Tabernaemontana crassa and Treculia Africana. T. Africana showed moderate anti-plasmodial activity with IC50 value of 6.62 µg/mL. Extracts of P. clappertoniana, T. Africana and T. ivorensis (0.4 mg/mL) showed >50% antioxidant effect (SOD). The extracts were not cytotoxicity towards RBCs at the concentration tested (200 µg/ml) but were weakly cytotoxic to HL-60 cell. Selectivity indices of most of the extracts were greater than 10. Our results suggest that most of the plant extracts have strong anti-plasmodial activity and antioxidant activity which warrants further investigations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales Límite: Humans País/Región como asunto: Africa Idioma: En Revista: J Evid Based Integr Med Año: 2022 Tipo del documento: Article País de afiliación: Ghana Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales Límite: Humans País/Región como asunto: Africa Idioma: En Revista: J Evid Based Integr Med Año: 2022 Tipo del documento: Article País de afiliación: Ghana Pais de publicación: Estados Unidos