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A review on bacterial redox dependent iron transporters and their evolutionary relationship.
Banerjee, Sambuddha; Chanakira, Mina N; Hall, Jonathan; Kerkan, Alexa; Dasgupta, Saumya; Martin, Daniel W.
Afiliación
  • Banerjee S; Department of Chemistry, East Carolina University, Greenville, NC 27858, USA. Electronic address: banerjees17@ecu.edu.
  • Chanakira MN; Department of Chemistry, East Carolina University, Greenville, NC 27858, USA.
  • Hall J; Department of Chemistry, East Carolina University, Greenville, NC 27858, USA.
  • Kerkan A; Department of Chemistry, East Carolina University, Greenville, NC 27858, USA.
  • Dasgupta S; Department of Chemistry, Amity Institute of Applied Sciences, Amity University Kolkata, WB 700135, India.
  • Martin DW; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
J Inorg Biochem ; 229: 111721, 2022 04.
Article en En | MEDLINE | ID: mdl-35033753
Iron is an essential yet toxic micronutrient and its transport across biological membranes is tightly regulated in all living organisms. One such iron transporter, the Ftr-type permeases, is found in both eukaryotic and prokaryotic cells. These Ftr-type transporters are required for iron transport, predicted to form α-helical transmembrane structures, and conserve two ArgGluxxGlu (x = any amino acid) motifs. In the yeast Ftr transporter (Ftr1p), a ferroxidase (Fet3p) is required for iron transport in an oxidation coupled transport step. None of the bacterial Ftr-type transporters (EfeU and FetM from E. coli; cFtr from Campylobacter jejuni; FtrC from Brucella, Bordetella, and Burkholderia spp.) contain a ferroxidase protein. Bioinformatics report predicted periplasmic EfeO and FtrB (from the EfeUOB and FtrABCD systems) as novel cupredoxins. The Cu2+ binding and the ferrous oxidation properties of these proteins are uncharacterized and the other two bacterial Ftr-systems are expressed without any ferroxidase/cupredoxin, leading to controversy about the mode of function of these transporters. Here, we review published data on Ftr-type transporters to gain insight into their functional diversity. Based on original bioinformatics data presented here evolutionary relations between these systems are presented.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Proteínas Bacterianas / Proteínas de Transporte de Catión / Hierro Idioma: En Revista: J Inorg Biochem Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Proteínas Bacterianas / Proteínas de Transporte de Catión / Hierro Idioma: En Revista: J Inorg Biochem Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos