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Persistent dysglycemia is associated with unfavorable treatment outcomes in patients with pulmonary tuberculosis from Peru.
Calderon, Roger I; Arriaga, María B; Aliaga, Juan G; Barreda, Nadia N; Sanabria, Oswaldo M; Barreto-Duarte, Beatriz; Franco, João Pedro Duarte; Lecca, Leonid; Andrade, Bruno B; Carvalho, Anna Cristina Calçada; Kritski, Afrânio L.
Afiliación
  • Calderon RI; Socios En Salud Sucursal Peru, Lima 15001, Peru.; Programa Acadêmico de Tuberculose. Faculdade de Medicina. Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.; Grupo de Investigación en Bioquímica y Biología Sintética, Universidad Nacional Federico Villarreal, Lima, Peru.. Ele
  • Arriaga MB; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia 40269-710, Brazil.; Faculdade de Medicina, Universidade Federal da Bahia, Salvador, Bahia 40110-100, Brazil.; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazi
  • Aliaga JG; Socios En Salud Sucursal Peru, Lima 15001, Peru.. Electronic address: jgaliaga@gmail.com.
  • Barreda NN; Socios En Salud Sucursal Peru, Lima 15001, Peru.. Electronic address: nbarreda_ses@pih.org.
  • Sanabria OM; Socios En Salud Sucursal Peru, Lima 15001, Peru.. Electronic address: osanabria_ses@pih.org.
  • Barreto-Duarte B; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil; Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil; Curso de Medicina, Universidade Salvador (UNIFACS), Salvador,
  • Franco JPD; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil; Curso de Medicina, Universidade Salvador (UNIFACS), Salvador, Brazil. Electronic address: jpdfranco09@gmail.com.
  • Lecca L; Socios En Salud Sucursal Peru, Lima 15001, Peru.; Department of Global Health and Social Medicine. Harvard Medical School. Boston, United States of America.. Electronic address: llecca_ses@pih.org.
  • Andrade BB; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil; Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil; Curso de Medicina, Universidade Salvador (UNIFACS), Salvador,
  • Carvalho ACC; Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil.. Electronic address: anna.carvalho@ioc.fiocruz.br.
  • Kritski AL; Programa Acadêmico de Tuberculose. Faculdade de Medicina. Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.. Electronic address: kritskia@gmail.com.
Int J Infect Dis ; 116: 293-301, 2022 Mar.
Article en En | MEDLINE | ID: mdl-35033658
BACKGROUND: Dysglycemia (i.e., prediabetes or diabetes) in patients with tuberculosis (PWTB) is associated with increased odds of mortality and treatment failure. Whether such association holds true when dysglycemia is transient or persistent is unknown. In this study, we tested the association between persistent dysglycemia (PD) during anti-tuberculosis (TB) treatment and unfavorable treatment outcomes in PWTB from Lima, Peru. METHODS: PWTB enrolled between February and November 2017 were followed for 24-months. Dysglycemia was measured through fasting glucose and HbA1c at baseline during the 2nd- and 6th-month of TB treatment. PD was defined as dysglycemia detected in 2 different visits. The association between PD and unfavorable TB treatment outcome was evaluated using logistic regression. RESULTS: Among 125 PWTB, PD prevalence was 29.6%. PD was associated with more lung lesion types, higher bacillary loads, low hemoglobin (Hb), and high body mass index (BMI). Unfavorable TB treatment outcome was associated with older age, higher BMI, more lung lesion types, and PD. After adjusting for age, Hb levels, smoking, and smear grade, PD was independently associated with unfavorable treatment outcomes (adjusted odds ratio (aOR): 6.1; 95% CI: 1.9-19.6). CONCLUSION: PD is significantly associated with higher odds of unfavorable TB treatment outcomes. Dysglycemia control during anti-TB treatment gives the opportunity to introduce appropriate interventions to TB management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Prediabético / Tuberculosis / Tuberculosis Pulmonar Tipo de estudio: Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Peru Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article Pais de publicación: Canadá
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Prediabético / Tuberculosis / Tuberculosis Pulmonar Tipo de estudio: Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Peru Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2022 Tipo del documento: Article Pais de publicación: Canadá