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Functional status in older patients with lung cancer: an observational cohort study.
Couderc, Anne-Laure; Tomasini, Pascale; Greillier, Laurent; Nouguerède, Emilie; Rey, Dominique; Montegut, Coline; Thomas, Pascal-Alexandre; Barlesi, Fabrice; Villani, Patrick.
Afiliación
  • Couderc AL; Internal Medicine, Geriatrics and Therapeutic Unit, Assistance Publique-Hôpitaux de Marseille (AP-HM), Marseille, France. anne-laure.couderc@ap-hm.fr.
  • Tomasini P; Coordination Unit for Geriatric Oncology (UCOG) PACA West, Marseille University Hospital (AP-HM), 270 Boulevard de Sainte Marguerite, 13009, Marseille, France. anne-laure.couderc@ap-hm.fr.
  • Greillier L; Aix-Marseille University, CNRS, EFS, ADES, Marseille, France. anne-laure.couderc@ap-hm.fr.
  • Nouguerède E; Multidisciplinary Oncology and Therapeutic Innovations Department, AP-HM, Marseille, France.
  • Rey D; Aix-Marseille University, CNRS, INSERM, CRCM, Marseille, France.
  • Montegut C; Multidisciplinary Oncology and Therapeutic Innovations Department, AP-HM, Marseille, France.
  • Thomas PA; Aix-Marseille University, CNRS, INSERM, CRCM, Marseille, France.
  • Barlesi F; Internal Medicine, Geriatrics and Therapeutic Unit, Assistance Publique-Hôpitaux de Marseille (AP-HM), Marseille, France.
  • Villani P; Coordination Unit for Geriatric Oncology (UCOG) PACA West, Marseille University Hospital (AP-HM), 270 Boulevard de Sainte Marguerite, 13009, Marseille, France.
Support Care Cancer ; 30(5): 3817-3827, 2022 May.
Article en En | MEDLINE | ID: mdl-35031829
PURPOSE: An assessment of the impact of functional status (FS) evaluated using a combination of Activities of Daily Living (ADL) and the short version of the Instrumental Activities of Daily Living (IADL), on 3- and 6- month mortality and on 3-month unplanned hospitalizations in older patients treated for lung cancers. METHOD AND OBJECTIVES: This observational retrospective study was conducted between September 2015 and January 2019 at Marseille University Hospital (AP-HM). During this period, all consecutive outpatients aged 70 years or older referred for a comprehensive geriatric assessment (CGA) before the initiation of lung cancer treatment were enrolled. RESULTS: Two hundred twenty-seven patients were analyzed: the median age was 78.7 years and 74.0% were male. Almost half of the patients were metastatic (45.4%). Concerning FS, 41.9% of patients had no ADL-IADL impairment, 30.0% had either IADL or ADL impairment, and both ADL-IADL were impaired for 28.1%. Impaired ADL-IADL was associated with poor nutritional status, depression, mobility, and cognitive disorders. In a logistic regression model, ADL or IADL impairment (aOR = 2.1; 95% CI [1.0-4.2]; p = 0.037) and impaired ADL-IADL (aOR = 2.6; 95% CI [1.2-5.3]; p = 0.012) were independently associated with a higher risk of unplanned hospitalizations within 3 months. In the multivariate Cox model, 6-month mortality risk was independently associated with impaired ADL-IADL (aHR = 2.3; 95% CI [1.3-4.4]; p = 0.008). CONCLUSION: The combination of ADL and IADL scales to assess FS is a prognostic marker of the mortality risk at 6 months in older patients with lung cancer and should be more largely used by oncologists in treatment decision making.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Actividades Cotidianas / Neoplasias Pulmonares Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Actividades Cotidianas / Neoplasias Pulmonares Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania