Novel Mouse Model of Murine Cytomegalovirus-Induced Adaptive NK Cells.
Immunohorizons
; 6(1): 8-15, 2022 01 14.
Article
en En
| MEDLINE
| ID: mdl-35031582
NK cells are important mediators of viral control with the capacity to form adaptive immune features following infection. However, studies of infection-induced adaptive NK cells require adoptive cell transfer to lower the precursor frequency of "Ag-specific" NK cells, potentially limiting the diversity of the NK cell response. In seeking an unmanipulated model to probe the adaptive NK cells, we interrogated a wide range of Collaborative Cross (CC) inbred mice, inbred mouse strains that exhibit broad genetic diversity across strains. Our assessment identified and validated a putative "ideal" CC strain, CC006, which does not require manipulation to generate and maintain adaptive NK cells. Critically, CC006 mice, in contrast to C57BL/6 mice, are capable of developing enhanced NK cell-mediated protective responses to murine CMV infection following m157-mediated vaccination. This work both furthers our understanding of adaptive NK cells and demonstrates the utility of CC mice in the development and interrogation of immunologic models.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Asesinas Naturales
/
Muromegalovirus
/
Infecciones por Herpesviridae
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Modelos Animales de Enfermedad
Límite:
Animals
Idioma:
En
Revista:
Immunohorizons
Año:
2022
Tipo del documento:
Article
Pais de publicación:
Estados Unidos