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Evaluation of a Polyurethane Platform for Delivery of Nanohydroxyapatite and Decellularized Bone Particles in a Porous Three-Dimensional Scaffold.
Bow, Austin; Newby, Steven; Rifkin, Rebecca; Jackson, Bailey K; Matavosian, Alicia; Griffin, Christopher; King, William; Alghazali, Karrer; Mhannawee, Anwer; Berryhill, Stuart B; Morello, Roy; Hecht, Silke; Biris, Alexandru S; Anderson, David E; Bourdo, Shawn E; Dhar, Madhu.
Afiliación
  • Bow A; College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, United States.
  • Newby S; College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, United States.
  • Rifkin R; College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, United States.
  • Jackson BK; Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, Arkansas 72204, United States.
  • Matavosian A; College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, United States.
  • Griffin C; Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, Arkansas 72204, United States.
  • King W; Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, Arkansas 72204, United States.
  • Alghazali K; Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, Arkansas 72204, United States.
  • Mhannawee A; Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, Arkansas 72204, United States.
  • Berryhill SB; University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
  • Morello R; University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
  • Hecht S; College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, United States.
  • Biris AS; Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, Arkansas 72204, United States.
  • Anderson DE; College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, United States.
  • Bourdo SE; Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, Arkansas 72204, United States.
  • Dhar M; College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996, United States.
ACS Appl Bio Mater ; 2(5): 1815-1829, 2019 May 20.
Article en En | MEDLINE | ID: mdl-35030672
The complex dynamic nature of bone tissue presents a unique challenge for developing optimal biomaterials within the field of bone tissue engineering. Materials based on biological and physiological characteristics of natural bone have shown promise for inducing and promoting effective bone repair. Design of multicomposite scaffolds that incorporate both malleable and hard mineral components allows for intricate structures with nano- and macrosized mineral components to provide architectural elements that promote osteogenesis. The examined S-1 and S-2 scaffolds are multilayered constructs which differ only in the compositional ratio of nanohydroxyapatite (nHA) and decellularized bone particles (DBPs). The constructs incorporated previously studied nHA/polyurethane films interspersed with macrosized bone DBPs to stimulate integration with native tissue and induce osteogenic activity. In vitro assessment of cytocompatibility and osteostimulatory characteristics indicated that the scaffolds did not negatively impact cell health and demonstrated osteogenic effects. When the constructs were implanted in vivo, in a rat tibial defect model, the biocompatibility and osteogenic impact were confirmed. Material-treated defects were observed to not induce negative tissue reactions and, in those treated with S-1 scaffolds, exhibited greater levels of new bone formation. These results indicate that, while both scaffold designs were biocompatible, S-1 constructs demonstrate more effective biologically relevant nano-/macromineral architectural elements.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: ACS Appl Bio Mater Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: ACS Appl Bio Mater Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos