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Fabrication of 3D scaffolds based on fully biobased unsaturated polyester resins by microstereo-lithography.
Gonçalves, Filipa A M M; Fonseca, Ana C; Cordeiro, Rosemeyre; Piedade, Ana P; Faneca, Henrique; Serra, Arménio; Coelho, Jorge F J.
Afiliación
  • Gonçalves FAMM; CIEPQPF-Department of Chemical Engineering, University of Coimbra, 3030-790 Coimbra, Portugal.
  • Fonseca AC; CEMMPRE-Centre for Mechanical Engineering, Materials and Processes, Chemical Engineering Department, University of Coimbra, 3030-790 Coimbra, Portugal.
  • Cordeiro R; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
  • Piedade AP; CEMMPRE-Centre for Mechanical Engineering, Materials and Processes, Mechanical Engineering Department, University of Coimbra, 3030-788 Coimbra, Portugal.
  • Faneca H; Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.
  • Serra A; CEMMPRE-Centre for Mechanical Engineering, Materials and Processes, Chemical Engineering Department, University of Coimbra, 3030-790 Coimbra, Portugal.
  • Coelho JFJ; CEMMPRE-Centre for Mechanical Engineering, Materials and Processes, Chemical Engineering Department, University of Coimbra, 3030-790 Coimbra, Portugal.
Biomed Mater ; 17(2)2022 02 03.
Article en En | MEDLINE | ID: mdl-35026736
Additive Manufacturing (AM) technologies are an effective route to fabricate tailor made scaffolds for tissue engineering (TE) and regenerative medicine, with microstereo-lithography (µSLA) being one of the most promising techniques to produce high quality 3D structures. Here, we report the crosslinking studies of fully biobased unsaturated polyesters (UPs) with 2-hydroxyethyl methacrylate (HEMA) as the unsaturated monomer (UM), using thermal and µSLA crosslinking processes. The resulting resins were fully characterized in terms of their thermal and mechanical properties. Determination of gel content, water contact angle, topography and morphology analysis by atomic force microscopy and scanning electron microscopy were also performed. The results show that the developed UP resins (UPRs) have promising properties for µSLA.In vitrocytotoxicity assays performed with 3T3-L1 cell lines showed that the untreated scaffolds exhibited a maximum cellular viability around 60%, which was attributed to the acidic nature of the UPRs. The treatment of the UPRs and scaffolds with ethanol (EtOH) improved the cellular viability to 100%. The data presented in this manuscript contribute to improve the performance of biobased UPs in AM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Andamios del Tejido / Estereolitografía / Metacrilatos Límite: Animals Idioma: En Revista: Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2022 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Andamios del Tejido / Estereolitografía / Metacrilatos Límite: Animals Idioma: En Revista: Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2022 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido