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Structural brain abnormalities in adolescent patients with anorexia nervosa at both the acute and weight-recovered phase.
Asami, Takeshi; Takaishi, Masao; Nakamura, Ryota; Yoshimi, Asuka; Konishi, Jun; Aoyama, Kumi; Fujita, Junichi; Miyazaki, Hidehito; Aoki, Yoshiko; Asanuma, Kazuya; Hattori, Saki; Suda, Akira; Whitford, Thomas J; Hirayasu, Yoshio; Hishimoto, Akitoyo.
Afiliación
  • Asami T; Department of Psychiatry, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Japan. t_asami@yokohama-cu.ac.jp.
  • Takaishi M; Department of Psychiatry, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Japan.
  • Nakamura R; Psychiatric Center, Yokohama City University Medical Center, Yokohama, Japan.
  • Yoshimi A; Department of Psychiatry, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Japan.
  • Konishi J; Disabled Persons Health and Welfare Department, Health and Social Welfare Bureau, Mental Health Counseling Center, City of Yokohama, Japan.
  • Aoyama K; Psychiatric Center, Yokohama City University Medical Center, Yokohama, Japan.
  • Fujita J; Department of Child Psychiatry, Yokohama City University Hospital, Yokohama, Japan.
  • Miyazaki H; Department of Child Psychiatry, Yokohama City University Hospital, Yokohama, Japan.
  • Aoki Y; Department of Child Psychiatry, Yokohama City University Hospital, Yokohama, Japan.
  • Asanuma K; Psychiatric Center, Yokohama City University Medical Center, Yokohama, Japan.
  • Hattori S; Department of Psychiatry, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Japan.
  • Suda A; Department of Psychiatry, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Japan.
  • Whitford TJ; School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
  • Hirayasu Y; Hirayasu Hospital, Urasoe, Japan.
  • Hishimoto A; Department of Psychiatry, Yokohama City University School of Medicine Graduate School of Medicine, Yokohama, Japan.
Brain Imaging Behav ; 16(3): 1372-1380, 2022 Jun.
Article en En | MEDLINE | ID: mdl-35025002
Previous cross-sectional studies have reported that adolescent patients with anorexia nervosa (AN) showed global gray matter volume (GMV) reductions at the acute phase which were restored at the weight-recovered phase, compared with healthy controls (HC). However, few studies have investigated white matter volume (WMV) or cortical thickness in the context of AN, and results have been inconsistent. Voxel-based morphometry analyses for GM and WM, and cortical thickness analyses for GM were conducted in 31 adolescent patients with AN (vs. 18 HC) in the acute phase, and 16 patients with AN (vs. 13 HC) in the follow-up weight-recovered phase, over an approximately 1-year follow-up interval. At the acute phase, the AN patients showed significant reductions of GMVs and cortical thickness in widespread brain regions, compared with HC. Significant WMV reductions were identified in the bilateral superior longitudinal fascicle, superior thalamic radiation, corona radiata, and fornix, pons, and medulla in the patients. At the weight-recovered phase, the AN patients showed a significant GMV reduction in the left hippocampus, and a WMV reduction in the pons, compared with the HC. There was no difference in cortical thickness between two groups at the weight-recovered phase. In conclusion, the widespread volumetric reductions in GM and WM, and reduced cortical thickness observed in AN patients in the acute phase were not evident in the follow-up weight-recovered phase. The volume reductions observed in the hippocampus and pons in the weight-recovered phase could potentially reflect delayed neurogenesis or recovery from starvation in the AN patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anorexia Nerviosa / Sustancia Blanca Tipo de estudio: Observational_studies Límite: Adolescent / Humans Idioma: En Revista: Brain Imaging Behav Asunto de la revista: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anorexia Nerviosa / Sustancia Blanca Tipo de estudio: Observational_studies Límite: Adolescent / Humans Idioma: En Revista: Brain Imaging Behav Asunto de la revista: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos