Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity.

Jilek, Joseph L; Frost, Kayla L; Jacobus, Kevyn A; He, Wenxi; Toth, Erica L; Goedken, Michael; Cherrington, Nathan J

Jilek, Joseph L; Frost, Kayla L; Jacobus, Kevyn A; He, Wenxi; Toth, Erica L; Goedken, Michael; Cherrington, Nathan J.

Afiliación

Jilek JL; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA.
Frost KL; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA.
Jacobus KA; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA.
He W; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA.
Toth EL; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA.
Goedken M; Rutgers Translational Sciences, Rutgers University, Piscataway, NJ 08901, USA.
Cherrington NJ; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA.

Acta Pharm Sin B ; 11(12): 3869-3878, 2021 Dec.

Article en En | MEDLINE | ID: mdl-35024313

Palabras clave

ATP7, ATPase copper transporting protein; CDDP, cisplatin; CTR, copper transporter; Cisplatin; DDTC, diethyldithiocarbamate; DT, drug transporter; Drug transporter; GFR, glomerular filtration rate; LCMS/MS, liquid chromatographytandem mass spectrometry; MATE, multidrug and toxin extrusion protein; MCD, methionine- and choline-deficient diet; NAFLD, nonalcoholic fatty liver disease; NASH; NASH, nonalcoholic steatohepatitis; Nephrotoxicity; Nonalcoholic steatohepatitis; OCT, organic cation transporter; P-gp, p-glycoprotein; PK, pharmacokinetics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Pharm Sin B Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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