Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia/reperfusion injury.

Wang, Ruiying; Wang, Min; Zhou, Jiahui; Dai, Ziru; Sun, Guibo; Sun, Xiaobo

Wang, Ruiying; Wang, Min; Zhou, Jiahui; Dai, Ziru; Sun, Guibo; Sun, Xiaobo.

Afiliación

Wang R; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Wang M; Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China.
Zhou J; Key Laboratory of New Drug Discovery Based on Classic Chinese Medicine Prescription, Chinese Academy of Medical Sciences, Beijing 100193, China.
Dai Z; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Sun G; Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China.
Sun X; Key Laboratory of New Drug Discovery Based on Classic Chinese Medicine Prescription, Chinese Academy of Medical Sciences, Beijing 100193, China.

J Adv Res ; 34: 173-186, 2021 12.

Article en En | MEDLINE | ID: mdl-35024189

Asunto(s)

Daño por Reperfusión Miocárdica; Saponinas; Proteínas Adaptadoras Transductoras de Señales; Animales; Apoptosis; Proteínas Reguladoras de la Apoptosis; Calcio/metabolismo; Canales de Calcio Tipo L/genética; Daño por Reperfusión Miocárdica/tratamiento farmacológico; Ácido Oleanólico/análogos & derivados; Ratas; Ratas Sprague-Dawley; Saponinas/farmacología

Palabras clave

Bcl2-associated athanogene 3; Calcium overload; Calenduloside E; L-type calcium channels; Myocardial ischemia/reperfusion injury

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saponinas / Daño por Reperfusión Miocárdica Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: J Adv Res Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Egipto

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