Molecularly pure miktoarm spherical nucleic acids: preparation and usage as a scaffold for abiotic intracellular catalysis.

Zhang, Bohan; Bai, Silei; Chao, Xiangyu; Wu, Tong; Chen, Zhiyong; Cheng, Zehong; Xiao, Yue; Zhang, Ke; Bai, Yugang

Zhang, Bohan; Bai, Silei; Chao, Xiangyu; Wu, Tong; Chen, Zhiyong; Cheng, Zehong; Xiao, Yue; Zhang, Ke; Bai, Yugang.

Afiliación

Zhang B; State Key Laboratory of Chem-/Bio-Sensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University Changsha Hunan 410082 China baiyugang@hnu.edu.cn.
Bai S; State Key Laboratory of Chem-/Bio-Sensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University Changsha Hunan 410082 China baiyugang@hnu.edu.cn.
Chao X; State Key Laboratory of Chem-/Bio-Sensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University Changsha Hunan 410082 China baiyugang@hnu.edu.cn.
Wu T; State Key Laboratory of Chem-/Bio-Sensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University Changsha Hunan 410082 China baiyugang@hnu.edu.cn.
Chen Z; State Key Laboratory of Chem-/Bio-Sensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University Changsha Hunan 410082 China baiyugang@hnu.edu.cn.
Cheng Z; State Key Laboratory of Chem-/Bio-Sensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, College of Chemistry and Chemical Engineering, Hunan University Changsha Hunan 410082 China baiyugang@hnu.edu.cn.
Xiao Y; School of Chemistry and Chemical Engineering, Zhengzhou University Zhengzhou Henan 450001 China.
Zhang K; School of Chemistry and Chemical Engineering, Zhengzhou University Zhengzhou Henan 450001 China.
Bai Y; Department of Chemistry and Chemical Biology, Northeastern University Boston MA 02115 USA.

Chem Sci ; 12(48): 15843-15848, 2021 Dec 15.

Article en En | MEDLINE | ID: mdl-35024108

RESUMEN

We present a fullerene-based strategy that allows the synthesis of molecularly pure miktoarm spherical nucleic acids (SNAs) with diverse structures, which, with post-functionalization, could serve as efficient scaffolds for intracellular catalysis. The SNA structure promotes cell permeability, nucleic acid stability, and catalytic efficiency, making the platform ideal for in cellulo reactions. Consequently, the tris(triazole)-bearing miktoarm SNA was able to effectively mediate intracellular copper-catalyzed alkyne-azide cycloaddition at nanomolar level of copper, and facilitate the same reaction in live zebrafish.

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google