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Amino/Amido Conjugates Form to Nanoscale Cobalt Physiometacomposite (PMC) Materials Functionally Delivering Nucleic Acid Therapeutic to Nucleus Enhancing Anticancer Activity via Ras-Targeted Protein Interference.
DeLong, Robert K; Dean, John; Glaspell, Garry; Jaberi-Douraki, Majid; Ghosh, Kartik; Davis, Daniel; Monteiro-Riviere, Nancy; Chandran, Parwathy; Nguyen, Tuyen; Aryal, Santosh; Middaugh, C Russell; Chan Park, Seok; Choi, Seong-O; Ramani, Meghana.
Afiliación
  • DeLong RK; Nanotechnology Innovation Center, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66502, United States.
  • Dean J; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, Missouri 63130, United States.
  • Glaspell G; US Army Corps of Engineers Engineer Research & Development Center, Alexandria, Virginia 22315, United States.
  • Jaberi-Douraki M; Institute for Computational Comparative Medicine, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66502, United States.
  • Ghosh K; Physics and Materials Science, Missouri State University, Springfield, Missouri 65897, United States.
  • Davis D; Animal Modeling Core, University of Missouri, Columbia, Missouri 65201, United States.
  • Monteiro-Riviere N; Nanotechnology Innovation Center, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66502, United States.
  • Chandran P; Nanotechnology Innovation Center, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66502, United States.
  • Nguyen T; Nanotechnology Innovation Center, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66502, United States.
  • Aryal S; Nanotechnology Innovation Center, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66502, United States.
  • Middaugh CR; Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 67047, United States.
  • Chan Park S; Nanotechnology Innovation Center, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66502, United States.
  • Choi SO; Nanotechnology Innovation Center, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66502, United States.
  • Ramani M; Nanotechnology Innovation Center, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66502, United States.
ACS Appl Bio Mater ; 3(1): 175-179, 2020 Jan 21.
Article en En | MEDLINE | ID: mdl-35019433
Aberrant splicing and protein interaction of Ras binding domain (RBD) are associated with melanoma drug resistance. Here, cobalt or nickel doped zinc oxide (ZnO) physiometacomposite (PMC) materials bind to RNA and peptide shown by Ninhydrin staining, UV-vis, Fourier transform infrared, and circular dichroism spectroscopy. PMCs deliver splice switching oligomer (SSO) into melanoma cells or 3-D tumor spheroids shown by flow cytometry, fluorescence microscopy, and bioluminescence. Stability in serum, liver, or tumor homogenate up to 48 h and B16F10 melanoma inhibition ≥98-99% is shown. These data suggest preclinical potential of PMC for delivery of SSO, RBD, or other nucleic acid therapeutic and anticancer peptides.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Appl Bio Mater Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Appl Bio Mater Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos