ASPER-29 suppresses the metastasis of pancreatic cancer cells by dual inhibition of cathepsin-L and cathepsin-S.

Yuan, Lei; Zhao, Juanping; Zhao, Songkun; Dong, Tianyi; Dong, Ruitong; Liu, Dongyue; Ma, Enlong; Li, Yanchun

Yuan, Lei; Zhao, Juanping; Zhao, Songkun; Dong, Tianyi; Dong, Ruitong; Liu, Dongyue; Ma, Enlong; Li, Yanchun.

Afiliación

Yuan L; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Zhao J; Department of Pharmacology, School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Zhao S; Department of Pharmacology, School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Dong T; Department of Pharmacology, School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Dong R; Department of Pharmacology, School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Liu D; Department of Pharmacology, School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Ma E; Department of Pharmacology, School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Li Y; Department of Pharmacology, School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: liyanchuntrue@hotmail.com.

Chem Biol Interact ; 353: 109811, 2022 Feb 01.

Article en En | MEDLINE | ID: mdl-35016848

Asunto(s)

Catepsina L/antagonistas & inhibidores; Catepsinas/antagonistas & inhibidores; Movimiento Celular/efectos de los fármacos; Inhibidores de Proteasas/farmacología; Animales; Antígenos CD/metabolismo; Antineoplásicos/química; Antineoplásicos/metabolismo; Antineoplásicos/farmacología; Antineoplásicos/uso terapéutico; Sitios de Unión; Catepsina L/metabolismo; Catepsinas/metabolismo; Moléculas de Adhesión Celular/antagonistas & inhibidores; Moléculas de Adhesión Celular/metabolismo; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Femenino; Proteínas Ligadas a GPI/antagonistas & inhibidores; Proteínas Ligadas a GPI/metabolismo; Humanos; Hígado/metabolismo; Hígado/patología; Pulmón/metabolismo; Pulmón/patología; Ratones; Ratones Desnudos; Simulación del Acoplamiento Molecular; Metástasis de la Neoplasia; Neoplasias Pancreáticas/tratamiento farmacológico; Neoplasias Pancreáticas/patología; Inhibidores de Proteasas/química; Inhibidores de Proteasas/metabolismo; Inhibidores de Proteasas/uso terapéutico; Trasplante Heterólogo

Palabras clave

Asperphenamate derivative; Cathepsin inhibitor; Metastasis; Molecular docking; Pancreatic cancer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Catepsinas / Movimiento Celular / Catepsina L Idioma: En Revista: Chem Biol Interact Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda

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