Your browser doesn't support javascript.
loading
Anesthesia and Developing Brains: Unanswered Questions and Proposed Paths Forward.
Ing, Caleb; Warner, David O; Sun, Lena S; Flick, Randall P; Davidson, Andrew J; Vutskits, Laszlo; McCann, Mary Ellen; O'Leary, James; Bellinger, David C; Rauh, Virginia; Orser, Beverley A; Suresh, Santhanam; Andropoulos, Dean B.
Afiliación
  • Ing C; Departments of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; the Department of Anesthesiology, Mailman School of Public Health, Columbia University, New York, New York.
  • Sun LS; Departments of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York; Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York.
  • Vutskits L; the e Department of Anesthesiology, Pharmacology, Intensive Care, and Emergency Medicine, University Hospitals of Geneva, Geneva, Switzerland.
  • McCann ME; the Department of Anesthesiology, Critical Care and Pain Medicine, Harvard Medical School, Boston, Massachusetts; the Departments of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts.
  • O'Leary J; the Department of Anesthesiology, Bon Secours Hospital, Cork, Ireland.
  • Bellinger DC; the Departments of Neurology and Psychiatry, Harvard Medical School, Boston, Massachusetts; Neurology and Psychiatry, Boston Children's Hospital, Boston, Massachusetts; the Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Rauh V; the Heilbrunn Department of Population and Family Health, Mailman School of Public Health, Columbia University, New York, New York.
  • Orser BA; the Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Suresh S; the Departments of Anesthesiology and Pediatrics, Northwestern University, Chicago, Illinois.
  • Andropoulos DB; the Departments of Anesthesiology and Pediatrics, Texas Children's Hospital, Houston, Texas.
Anesthesiology ; 136(3): 500-512, 2022 03 01.
Article en En | MEDLINE | ID: mdl-35015802
Anesthetic agents disrupt neurodevelopment in animal models, but evidence in humans is mixed. The morphologic and behavioral changes observed across many species predicted that deficits should be seen in humans, but identifying a phenotype of injury in children has been challenging. It is increasingly clear that in children, a brief or single early anesthetic exposure is not associated with deficits in a range of neurodevelopmental outcomes including broad measures of intelligence. Deficits in other domains including behavior, however, are more consistently reported in humans and also reflect findings from nonhuman primates. The possibility that behavioral deficits are a phenotype, as well as the entire concept of anesthetic neurotoxicity in children, remains a source of intense debate. The purpose of this report is to describe consensus and disagreement among experts, summarize preclinical and clinical evidence, suggest pathways for future clinical research, and compare studies of anesthetic agents to other suspected neurotoxins.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Síndromes de Neurotoxicidad / Anestesia General / Anestésicos Tipo de estudio: Prognostic_studies Límite: Animals / Child / Child, preschool / Humans / Infant Idioma: En Revista: Anesthesiology Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Síndromes de Neurotoxicidad / Anestesia General / Anestésicos Tipo de estudio: Prognostic_studies Límite: Animals / Child / Child, preschool / Humans / Infant Idioma: En Revista: Anesthesiology Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos