Your browser doesn't support javascript.
loading
Generation of induced pluripotent stem cell line, ICGi034-A, by reprogramming peripheral blood mononuclear cells from a patient with Parkinson's disease associated with GBA mutation.
Grigor'eva, Elena V; Drozdova, Elena S; Sorogina, Diana A; Malakhova, Anastasia A; Pavlova, Sofia V; Vyatkin, Yuri V; Khabarova, Elena A; Rzaev, Jamil A; Medvedev, Sergey P; Zakian, Suren M.
Afiliación
  • Grigor'eva EV; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia. Electronic address: evlena@bionet.nsc.ru.
  • Drozdova ES; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia.
  • Sorogina DA; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia.
  • Malakhova AA; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
  • Pavlova SV; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
  • Vyatkin YV; Novosibirsk State University, Novosibirsk, Russia.
  • Khabarova EA; FSBI Federal Neurosurgical Center, Novosibirsk, Russia.
  • Rzaev JA; FSBI Federal Neurosurgical Center, Novosibirsk, Russia.
  • Medvedev SP; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
  • Zakian SM; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
Stem Cell Res ; 59: 102651, 2022 Mar.
Article en En | MEDLINE | ID: mdl-35007918
Mutation in the glucocerebrosidase encoding gene (GBA) is one of the most frequent genetic cause of Parkinson's disease. ICGi034-A induced pluripotent stem cell (iPSC) line obtained by reprogramming peripheral blood mononuclear cells (PBMCs) of a patient with heterozygous c.1226A > G (p.N370S) mutation in the GBA gene can be used for studying the fundamental mechanisms of the pathogenesis of GBA-associated Parkinson's disease, and for potential drug screening. The iPSCs express pluripotency markers (NANOG, SSEA4, TRA-1-60, OCT4, SOX2), have a normal karyotype, and are capable of producing derivatives of three germ layers.
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Stem Cell Res Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Stem Cell Res Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido