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Targeted Delivery of Doxorubicin Using Transferrin-Conjugated Carbon Dots for Cancer Therapy.
Li, Lihong; Zhang, Qi; Li, Jinyao; Tian, Yafei; Kang, Yu; Ren, Guodong; Liu, Wen; Wang, Haojiang; Wang, Bin; Yan, Lili; Guo, Lixia; Diao, Haipeng.
Afiliación
  • Li L; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, PR China.
  • Zhang Q; College of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR China.
  • Li J; Key Laboratory of Cellular Physiology, Shanxi Medical University, Ministry of Education, Taiyuan 030001, PR China.
  • Tian Y; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, PR China.
  • Kang Y; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, PR China.
  • Ren G; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, PR China.
  • Liu W; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, PR China.
  • Wang H; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, PR China.
  • Wang B; College of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR China.
  • Yan L; Key Laboratory of Cellular Physiology, Shanxi Medical University, Ministry of Education, Taiyuan 030001, PR China.
  • Guo L; College of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR China.
  • Diao H; College of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR China.
ACS Appl Bio Mater ; 4(9): 7280-7289, 2021 09 20.
Article en En | MEDLINE | ID: mdl-35006957
A transferrin receptor (TfR)-targeted nanodrug [green fluorescence emission carbon dot (GCD)-polyethylene glycol (PEG)-transferrin (Tf)@doxorubicin (Dox)] for cancer therapy was developed by functionalizing GCDs with PEG, Tf, and Dox. GCDs were synthesized by the one-step hydrothermal method, followed by conjugating PEG and Tf by covalent bonds and loading Dox by electrostatic interactions. The nanodrug exhibits high stability under neutral conditions and effectively releases Dox at pH of 5.5. GCD-PEG-Tf@Dox can be selectively internalized by TfR-overexpressed tumor cells (MCF-7 and K150) via receptor-mediated endocytosis and further release Dox to the nuclei. As a result, GCD-PEG-Tf@Dox exhibits significant lethality to tumor cells (MCF-7 and K150) but greatly reduced toxicity to normal cells [Chinese hamster ovary cell line (CHO)] compared with free Dox. In vivo studies have confirmed that GCD-PEG-Tf@Dox can effectively inhibit tumor proliferation with negligible side effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transferrina / Neoplasias Límite: Animals Idioma: En Revista: ACS Appl Bio Mater Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transferrina / Neoplasias Límite: Animals Idioma: En Revista: ACS Appl Bio Mater Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos