Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments.

Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald; Sissolak, Bernhard

Bayer, Benjamin; Duerkop, Mark; Striedner, Gerald; Sissolak, Bernhard.

Afiliación

Bayer B; Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.
Duerkop M; Novasign GmbH, Vienna, Austria.
Striedner G; Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.
Sissolak B; Novasign GmbH, Vienna, Austria.

Front Bioeng Biotechnol ; 9: 740215, 2021.

Article en En | MEDLINE | ID: mdl-35004635

Palabras clave

Chinese hamster ovary cells; grey box; intensified DoE; monoclonal antibody; process optimization; quality by design; scale up; upstream processing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Bioeng Biotechnol Año: 2021 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza

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