Temporal evolution of brain distribution of IMP and HIPDM. Concise communication.
Nucl Med Commun
; 8(7): 597-602, 1987 Jul.
Article
en En
| MEDLINE
| ID: mdl-3500438
Early and late brain distribution of iodine-labelled N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine (HIPDM) and iodine labelled N-isopropyl-p-iodoamphetamine (IMP) were compared in rat and one human patient with a recent stroke in the right middle cerebral artery area. In rat, an important 'redistribution' of cerebral activity was observed in various areas of the brain, mainly white matter, whereas no such observation was made with HIPDM. In the patient, the right area was hypoactive during the early SPECT with IMP and HIPDM, and redistribution was observed in the late SPECT only with IMP. We suggest that while HIPDM appears to reflect regional cerebral perfusion, IMP distribution is dependent upon metabolic brain activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Tomografía Computarizada de Emisión
/
Anfetaminas
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Radioisótopos de Yodo
/
Yodobencenos
Límite:
Aged
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Animals
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Humans
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Male
Idioma:
En
Revista:
Nucl Med Commun
Año:
1987
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido