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Effects of Boron Neutron Capture Therapy on the Growth of Subcutaneous Xenografts of Human Colorectal Adenocarcinoma SW-620 in Immunodeficient Mice.
Kanygin, V V; Kasatova, A I; Zavjalov, E L; Razumov, I A; Kolesnikov, S I; Kichigin, A I; Solov'eva, O I; Tsygankova, A R; Taskaev, S Yu; Kasatov, D A; Sycheva, T V; Byvaltsev, V A.
Afiliación
  • Kanygin VV; Novosibirsk National Research State University, Novosibirsk, Russia.
  • Kasatova AI; Novosibirsk National Research State University, Novosibirsk, Russia.
  • Zavjalov EL; G. I. Budker Institute of Nuclear Physics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia.
  • Razumov IA; Novosibirsk National Research State University, Novosibirsk, Russia.
  • Kolesnikov SI; Federal Research Centre Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia.
  • Kichigin AI; Novosibirsk National Research State University, Novosibirsk, Russia.
  • Solov'eva OI; Federal Research Centre Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia.
  • Tsygankova AR; Research Center for Problems of Family Health and Human Reproduction, Irkutsk, Russia.
  • Taskaev SY; M. V. Lomonosov Moscow State University, Moscow, Russia.
  • Kasatov DA; Novosibirsk National Research State University, Novosibirsk, Russia.
  • Sycheva TV; Novosibirsk National Research State University, Novosibirsk, Russia.
  • Byvaltsev VA; Federal Research Centre Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med ; 172(3): 359-363, 2022 Jan.
Article en En | MEDLINE | ID: mdl-35001306
Boron neutron capture therapy (BNCT) can become an instrument for patients with malignant neoplasms of the rectum and colon. Here we evaluate the effectiveness of BNCT performed at the accelerator based epithermal neutron source at G. I. Budker Institute of Nuclear Physics, Siberian Division of Russian Academy of Sciences, in relation to subcutaneous xenografts of human colon adenocarcinoma SW-620 in SCID mice. Utilization of BNCT with boronоphenylalanine (BPA) and sodium borocaptate (BSH), which were injected intravenously into the retroorbital sinus, resulted in a significant decrease in tumor volumes compared to the control group (no radiation).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Neoplasias Colorrectales / Adenocarcinoma / Terapia por Captura de Neutrón de Boro Límite: Animals / Humans Idioma: En Revista: Bull Exp Biol Med Año: 2022 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Neoplasias Colorrectales / Adenocarcinoma / Terapia por Captura de Neutrón de Boro Límite: Animals / Humans Idioma: En Revista: Bull Exp Biol Med Año: 2022 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos