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BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment.
Abellaneda-Pérez, Kilian; Martin-Trias, Pablo; Cassé-Perrot, Catherine; Vaqué-Alcázar, Lídia; Lanteaume, Laura; Solana, Elisabeth; Babiloni, Claudio; Lizio, Roberta; Junqué, Carme; Bargalló, Núria; Rossini, Paolo Maria; Micallef, Joëlle; Truillet, Romain; Charles, Estelle; Jouve, Elisabeth; Bordet, Régis; Santamaria, Joan; Rossi, Simone; Pascual-Leone, Alvaro; Blin, Olivier; Richardson, Jill; Jovicich, Jorge; Bartrés-Faz, David.
Afiliación
  • Abellaneda-Pérez K; Medical Psychology Unit, Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, C/ Casanova, 143, 08036, Barcelona, Spain.
  • Martin-Trias P; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Cassé-Perrot C; Medical Psychology Unit, Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, C/ Casanova, 143, 08036, Barcelona, Spain.
  • Vaqué-Alcázar L; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Lanteaume L; CIC CPCET Service de Pharmacologie Clinique et Pharmacovigilance, CHU Timone, AP-HM, Marseille, France.
  • Solana E; Medical Psychology Unit, Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, C/ Casanova, 143, 08036, Barcelona, Spain.
  • Babiloni C; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Lizio R; CIC CPCET Service de Pharmacologie Clinique et Pharmacovigilance, CHU Timone, AP-HM, Marseille, France.
  • Junqué C; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Bargalló N; Department of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, Rome, Italy.
  • Rossini PM; Department of Neuroscience and Neurorehabilitation, IRCCS S. Raffaele, Roma, Italy.
  • Micallef J; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) SDN, Naples, Italy.
  • Truillet R; Medical Psychology Unit, Department of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, C/ Casanova, 143, 08036, Barcelona, Spain.
  • Charles E; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
  • Jouve E; Neuroradiology Section, Radiology Department, Diagnostic Image Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.
  • Bordet R; Magnetic Resonance Image Core Facility (IDIBAPS), Barcelona, Spain.
  • Santamaria J; Department of Neuroscience and Neurorehabilitation, IRCCS S. Raffaele, Roma, Italy.
  • Rossi S; CIC CPCET Service de Pharmacologie Clinique et Pharmacovigilance, CHU Timone, AP-HM, Marseille, France.
  • Pascual-Leone A; INSERM, Inst Neurosci Syst, Aix Marseille Université, 13005, Marseille, France.
  • Blin O; CIC CPCET Service de Pharmacologie Clinique et Pharmacovigilance, CHU Timone, AP-HM, Marseille, France.
  • Richardson J; CIC CPCET Service de Pharmacologie Clinique et Pharmacovigilance, CHU Timone, AP-HM, Marseille, France.
  • Jovicich J; CIC CPCET Service de Pharmacologie Clinique et Pharmacovigilance, CHU Timone, AP-HM, Marseille, France.
  • Bartrés-Faz D; Inserm, CHU Lille, U1171, Degenerative and Vascular Cognitive Disorders, University of Lille, Lille, France.
Sci Rep ; 12(1): 176, 2022 01 07.
Article en En | MEDLINE | ID: mdl-34997117
The BDNF Val66Met gene polymorphism is a relevant factor explaining inter-individual differences to TMS responses in studies of the motor system. However, whether this variant also contributes to TMS-induced memory effects, as well as their underlying brain mechanisms, remains unexplored. In this investigation, we applied rTMS during encoding of a visual memory task either over the left frontal cortex (LFC; experimental condition) or the cranial vertex (control condition). Subsequently, individuals underwent a recognition memory phase during a functional MRI acquisition. We included 43 young volunteers and classified them as 19 Met allele carriers and 24 as Val/Val individuals. The results revealed that rTMS delivered over LFC compared to vertex stimulation resulted in reduced memory performance only amongst Val/Val allele carriers. This genetic group also exhibited greater fMRI brain activity during memory recognition, mainly over frontal regions, which was positively associated with cognitive performance. We concluded that BDNF Val66Met gene polymorphism, known to exert a significant effect on neuroplasticity, modulates the impact of rTMS both at the cognitive as well as at the associated brain networks expression levels. This data provides new insights on the brain mechanisms explaining cognitive inter-individual differences to TMS, and may inform future, more individually-tailored rTMS interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Factor Neurotrófico Derivado del Encéfalo / Ondas Encefálicas / Estimulación Transcraneal de Corriente Directa / Lóbulo Frontal / Memoria / Trastornos de la Memoria Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Adult / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Factor Neurotrófico Derivado del Encéfalo / Ondas Encefálicas / Estimulación Transcraneal de Corriente Directa / Lóbulo Frontal / Memoria / Trastornos de la Memoria Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Adult / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido