Caffeic acid protects against DNA damage, oxidative and inflammatory mediated toxicities, and upregulated caspases activation in the hepatorenal system of rats treated with aflatoxin B<sub>1</sub>.

Owumi, Solomon E; Irozuru, Chioma E; Arunsi, Uche O; Oyelere, Adegboyega K

Caffeic acid protects against DNA damage, oxidative and inflammatory mediated toxicities, and upregulated caspases activation in the hepatorenal system of rats treated with aflatoxin B₁.

Owumi, Solomon E; Irozuru, Chioma E; Arunsi, Uche O; Oyelere, Adegboyega K.

Afiliación

Owumi SE; Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, 200004, Nigeria. Electronic address: zicri@hotmail.com.
Irozuru CE; Molecular Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, 200004, Nigeria.
Arunsi UO; Department of Cancer Immunology and Biotechnology, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.
Oyelere AK; School of Chemistry & Biochemistry, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332-0400, USA.

Toxicon ; 207: 1-12, 2022 Feb.

Article en En | MEDLINE | ID: mdl-34995555

Asunto(s)

Aflatoxina B1; Hígado; Aflatoxina B1/metabolismo; Aflatoxina B1/toxicidad; Animales; Ácidos Cafeicos; Caspasas/metabolismo; Daño del ADN; Hígado/metabolismo; Masculino; Estrés Oxidativo; Ratas

Palabras clave

Aflatoxin B(1); Apoptosis; Caffeic acid; DNA damage; Hepatorenal toxicity; Oxido-inflammatory stress

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aflatoxina B1 / Hígado Límite: Animals Idioma: En Revista: Toxicon Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido

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