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Twenty-first Century Trends in the Global Epidemiology of Pediatric-Onset Inflammatory Bowel Disease: Systematic Review.
Kuenzig, M Ellen; Fung, Stephen G; Marderfeld, Luba; Mak, Joyce W Y; Kaplan, Gilaad G; Ng, Siew C; Wilson, David C; Cameron, Fiona; Henderson, Paul; Kotze, Paulo G; Bhatti, Jasmine; Fang, Vixey; Gerber, Samantha; Guay, Evelyne; Kotteduwa Jayawarden, Supun; Kadota, Leo; Maldonado D, Fernando; Osei, Jessica Amankwah; Sandarage, Ryan; Stanton, Amanda; Wan, Melissa; Benchimol, Eric I.
Afiliación
  • Kuenzig ME; SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada; Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada; CHEO Inflammatory Bowel Disease Centre, Division of G
  • Fung SG; CHEO Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, CHEO, Ottawa, Ontario, Canada; CHEO Research Institute, Ottawa, Ontario, Canada.
  • Marderfeld L; CHEO Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, CHEO, Ottawa, Ontario, Canada; CHEO Research Institute, Ottawa, Ontario, Canada.
  • Mak JWY; Department of Medicine and Therapeutics, Institute of Digestive Disease, LKS Institute of Health Science, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.
  • Kaplan GG; Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
  • Ng SC; Department of Medicine and Therapeutics, Institute of Digestive Disease, LKS Institute of Health Science, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.
  • Wilson DC; Department of Paediatric Gastroenterology and Nutrition, Royal Hospital for Sick Children and Young People, Edinburgh, United Kingdom; Child Life and Health, University of Edinburgh, Edinburgh, United Kingdom.
  • Cameron F; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom.
  • Henderson P; Department of Paediatric Gastroenterology and Nutrition, Royal Hospital for Sick Children and Young People, Edinburgh, United Kingdom; Child Life and Health, University of Edinburgh, Edinburgh, United Kingdom.
  • Kotze PG; IBD Outpatients Clinic, Colorectal Surgery Unit, Catholic University of Paraná (PUCPR), Curitiba, Brazil.
  • Bhatti J; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Fang V; SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada; Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada.
  • Gerber S; Department of Pediatrics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
  • Guay E; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Kotteduwa Jayawarden S; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Kadota L; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Maldonado D F; Department of Community Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Research Department, Saskatchewan Health Authority, Saskatoon, Saskatchewan, Canada.
  • Osei JA; Department of Community Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
  • Sandarage R; Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Stanton A; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
  • Wan M; Public Health and Preventive Medicine Residency Program, Department of Family Medicine, Queen's University, Kingston, Ontario, Canada.
  • Benchimol EI; SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada; Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada; CHEO Inflammatory Bowel Disease Centre, Division of G
Gastroenterology ; 162(4): 1147-1159.e4, 2022 04.
Article en En | MEDLINE | ID: mdl-34995526
BACKGROUND & AIMS: The incidence of inflammatory bowel disease (IBD) is increasing internationally, particularly in nations with historically low rates. Previous reports of the epidemiology of pediatric-onset IBD identified a paucity of data. We systematically reviewed the global trends in incidence and prevalence of IBD diagnosed in individuals <21 years old over the first 2 decades of the 21st century. METHODS: We systematically reviewed studies indexed in MEDLINE, EMBASE, Airiti Library, and SciELO from January 2010 to February 2020 to identify population-based studies reporting the incidence and/or prevalence of IBD, Crohn's disease, ulcerative colitis, and/or IBD-unclassified. Data from studies published before 2000 were derived from a previously published systematic review. We described the geographic distribution and trends in children of all ages and limiting to very early onset (VEO) IBD. RESULTS: A total of 131 studies from 48 countries were included. The incidence and prevalence of pediatric-onset IBD is highest in Northern Europe and North America and lowest in Southern Europe, Asia, and the Middle East. Among studies evaluating trends over time, most (31 of 37, 84%) studies reported significant increases in incidence and all (7 of 7) reported significant increases in prevalence. Data on the incidence and prevalence of VEO-IBD are limited to countries with historically high rates of IBD. Time trends in the incidence of VEO-IBD were visually heterogeneous. CONCLUSIONS: Rates of pediatric-onset IBD continue to rise around the world and data are emerging from regions where it was not previously reported; however, there remains a paucity of data on VEO-IBD and on pediatric IBD from developing and recently developed countries.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Colitis Ulcerosa / Enfermedad de Crohn Tipo de estudio: Diagnostic_studies / Incidence_studies / Prevalence_studies / Prognostic_studies / Screening_studies / Systematic_reviews Límite: Adult / Child / Humans Idioma: En Revista: Gastroenterology Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Colitis Ulcerosa / Enfermedad de Crohn Tipo de estudio: Diagnostic_studies / Incidence_studies / Prevalence_studies / Prognostic_studies / Screening_studies / Systematic_reviews Límite: Adult / Child / Humans Idioma: En Revista: Gastroenterology Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos