Stress conditions promote <i>Leishmania</i> hybridization in vitro marked by expression of the ancestral gamete fusogen HAP2 as revealed by single-cell RNA-seq.

Louradour, Isabelle; Ferreira, Tiago Rodrigues; Duge, Emma; Karunaweera, Nadira; Paun, Andrea; Sacks, David

Stress conditions promote Leishmania hybridization in vitro marked by expression of the ancestral gamete fusogen HAP2 as revealed by single-cell RNA-seq.

Louradour, Isabelle; Ferreira, Tiago Rodrigues; Duge, Emma; Karunaweera, Nadira; Paun, Andrea; Sacks, David.

Afiliación

Louradour I; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, United States.
Ferreira TR; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, United States.
Duge E; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, United States.
Karunaweera N; Department of Parasitology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Paun A; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, United States.
Sacks D; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, United States.

Elife ; 112022 01 07.

Article en En | MEDLINE | ID: mdl-34994687

Asunto(s)

Expresión Génica; Genes Protozoarios; Hibridación Genética; Leishmania donovani/fisiología; Leishmania infantum/fisiología; Leishmania major/fisiología; Estrés Fisiológico; Técnicas In Vitro; Leishmania donovani/genética; Leishmania infantum/genética; Leishmania major/genética; RNA-Seq; Análisis de la Célula Individual

Palabras clave

"leishmania tropica", "leishmania donovani", "leishmania braziliensis" , "leishmania infantum; "scRNA-seq", "WGS", "NGS", "single-cell"; Hap2; Leishmania; genetics; genomics; hybridization; infectious disease; mating; meiosis; microbiology

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Fisiológico / Leishmania donovani / Expresión Génica / Genes Protozoarios / Leishmania major / Leishmania infantum / Hibridación Genética Idioma: En Revista: Elife Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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