Your browser doesn't support javascript.
loading
A study of lovastatin and L-arginine co-loaded PLGA nanomedicine for enhancing nitric oxide production and eNOS expression.
Wijaya, Andy; Wang, Yi; Tang, Dan; Zhong, Yuan; Liu, Boyan; Yan, Meng; Jiu, Quhui; Wu, Wei; Wang, Guixue.
Afiliación
  • Wijaya A; Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. david2015@cqu.edu.cn.
  • Wang Y; College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China.
  • Tang D; Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. david2015@cqu.edu.cn.
  • Zhong Y; Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. david2015@cqu.edu.cn.
  • Liu B; Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. david2015@cqu.edu.cn.
  • Yan M; Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. david2015@cqu.edu.cn.
  • Jiu Q; Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. david2015@cqu.edu.cn.
  • Wu W; Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. david2015@cqu.edu.cn.
  • Wang G; Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. david2015@cqu.edu.cn.
J Mater Chem B ; 10(4): 607-624, 2022 01 26.
Article en En | MEDLINE | ID: mdl-34994373
Nitric oxide (NO) is an exceptional endogenous biological gas that mediates and regulates physiological and pathological processes in the human body. However, its synthesis process is impaired during athero-progression and formation. Hence, a strategy to boost NO production and target endothelial nitric oxide synthase (eNOS) is crucial and intriguing in atherosclerosis (AS) management. Herein, we prepare L-arginine (LA) and lovastatin (LV) co-loaded PLGA nanomedicine to achieve sustainable release for enhancing NO production. The utilization of LA reveals that LA has dual contributions, acting as a NO donor and enhancing the solubility of LV by stabilizing PLGA NPs. PLGA-LA/LV demonstrated its potential to boost NO in vitro and in vivo confirmed using DAF-FM DA, augment eNOS and p-eNOS mRNA and protein levels, and suppress the ki67 proliferation marker in VSMCs; in addition, it lowers the total cholesterol level of blood plasma in C57BL/6 mice. Moreover, PLGA can protect the compound delivered and enhance the bioavailability to reach and get released in the blood circulation after oral administration. Collectively, our results endow a safe and efficient nanomedicine outcome, specifically with potential for AS management.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arginina / Lovastatina / Aterosclerosis / Óxido Nítrico Sintasa de Tipo III / Nanomedicina / Copolímero de Ácido Poliláctico-Ácido Poliglicólico / Óxido Nítrico Límite: Animals / Humans / Male Idioma: En Revista: J Mater Chem B Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arginina / Lovastatina / Aterosclerosis / Óxido Nítrico Sintasa de Tipo III / Nanomedicina / Copolímero de Ácido Poliláctico-Ácido Poliglicólico / Óxido Nítrico Límite: Animals / Humans / Male Idioma: En Revista: J Mater Chem B Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido