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Cassane-type diterpenes from roots of Pterolobium macropterum and their anti-inflammatory activity.
Raksat, Achara; Choodej, Siwattra; Aree, Thammarat; Nejad Ebrahimi, Samad; Pudhom, Khanitha.
Afiliación
  • Raksat A; Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
  • Choodej S; Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
  • Aree T; Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
  • Nejad Ebrahimi S; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran. Electronic address: s_ebrahimi@sbu.ac.ir.
  • Pudhom K; Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address: khanitha.p@chula.ac.th.
Phytochemistry ; 196: 113074, 2022 Apr.
Article en En | MEDLINE | ID: mdl-34990974
Eight undescribed cassane diterpenes, pterolobirins C-J, together with two known analogs, were isolated from the roots of Pterolobium macropterum. Their structures were characterized by extensive spectroscopic techniques including NMR, MS, ECD and X-ray crystallographic spectroscopy. The absolute configuration of pterolobirin J was confirmed by single-crystal X-ray diffraction data. The compounds were screened for their anti-inflammatory activity on the lipopolysaccharide (LPS) induced nitric oxide (NO) production in J774. A1 macrophage cells. Pterolobirin E and sucutinirane C displayed good NO inhibition with IC50 values of 24.44 ± 1.34 and 19.16 ± 1.22 µM, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caesalpinia / Diterpenos Idioma: En Revista: Phytochemistry Año: 2022 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caesalpinia / Diterpenos Idioma: En Revista: Phytochemistry Año: 2022 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido