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Mechanistic and therapeutic implications of EphA-4 receptor tyrosine kinase in the pathogenesis of Alzheimer's disease.
Ganguly, Devargya; Thomas, Joshua Abby; Ali, Abid; Kumar, Rahul.
Afiliación
  • Ganguly D; Department of Biotechnology, GITAM Institute of Sciences, GITAM (Deemed to be) University, Vishakhapatnam, India.
  • Thomas JA; Department of Biotechnology, GITAM Institute of Sciences, GITAM (Deemed to be) University, Vishakhapatnam, India.
  • Ali A; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.
  • Kumar R; Department of Biotechnology, GITAM Institute of Sciences, GITAM (Deemed to be) University, Vishakhapatnam, India.
Eur J Neurosci ; 56(9): 5532-5546, 2022 11.
Article en En | MEDLINE | ID: mdl-34989046
Erythropoietin-producing hepatoma (Eph) receptors belong to a family of tyrosine kinase receptors that plays a pivotal role in the development of the brain. Eph can be divided broadly into two groups, namely, EphA and EphB, comprising nine and five members, respectively. In recent years, the role of EphA-4 has become increasingly apparent in the onset of Alzheimer's disease (AD). Emerging evidence suggests that EphA-4 results in synaptic dysfunction, which in turn promotes the progression of AD. Moreover, pharmacological or genetic ablation of EphA-4 in the murine model of AD can alleviate the symptoms. The current review summarizes different pathways by which EphA-4 can influence pathogenesis. Since, majority of the studies had reported the protective effect of EphA-4 inhibition during AD, designing therapeutics based on decreasing its enzymatic activity might be necessary for introducing the novel interventions. Therefore, the review described peptide and nanobodies inhibitors of EphA-4 that exhibit the potential to modulate EphA-4 and could be used as lead molecules for the targeted therapy of AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Eur J Neurosci Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Eur J Neurosci Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Francia