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Effects of hyperuricaemia, with the superposition of being overweight and hyperlipidaemia, on the incidence of acute kidney injury following cardiac surgery: a retrospective cohort study.
Su, Yiqi; Li, Haoxuan; Li, Yang; Xu, Xialian; Shen, Bo; Jiang, Wuhua; Wang, Yimei; Fang, Yi; Wang, Chunsheng; Luo, Zhe; Ding, Xiaoqiang; Teng, Jie; Xu, Jiarui.
Afiliación
  • Su Y; Department of Nephrology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.
  • Li H; Department of Nephrology, Shanghai Jing'an District Central Hospital, Shanghai, China.
  • Li Y; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Xu X; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Shen B; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Jiang W; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Wang Y; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Fang Y; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Wang C; Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Luo Z; Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Ding X; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Teng J; Department of Nephrology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China xu.jiarui@zs-hospital.sh.cn teng.jie@zs-hospital.sh.cn.
  • Xu J; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
BMJ Open ; 12(1): e047090, 2022 01 05.
Article en En | MEDLINE | ID: mdl-34987035
OBJECTIVES: Acute kidney injury (AKI) is a common complication of cardiac surgery. This study aimed to explore the effects of hyperuricaemia, being overweight and hyperlipidaemia as risk factors for AKI in patients following cardiac surgery (cardiac surgery-associated acute kidney injury (CSA-AKI)). DESIGN: Retrospective observational study. SETTING: University teaching, grade-A tertiary hospital in Shanghai, China. PARTICIPANTS: Patients who underwent cardiac surgery from July 2015 to December 2015 in Zhongshan Hospital, Fudan University. MAIN OUTCOME MEASURES: We investigated the effect of hyperuricaemia, in combination with being overweight and hyperlipidaemia, on the risk of CSA-AKI. RESULTS: A total of 1420 patients were enrolled. The AKI incidence in the highest uric acid group was 44.4%, while that in the lowest uric acid group was 28.5% (p<0.001). Patients in the higher uric acid quartiles were more likely to be overweight and hyperlipidaemic at the same time (p<0.001). Multivariate logistic regression analysis showed that hyperuricaemia was an independent risk factor for AKI (OR=1.237, 95% CI 1.095 to 1.885; p=0.009); being overweight or hyperlipidaemia alone was not an independent risk factor, but the combination of being overweight and hyperlipidaemia was (OR=1.544, 95% CI 1.059 to 2.252; p=0.024). In the final model, the OR value increased to 3.126 when hyperuricaemia was combined with being overweight and hyperlipidaemia, and the Hosmer-Lemeshow test showed that all three models fit well (p=0.433, 0.638 and 0.597, respectively). CONCLUSIONS: The combination of being overweight and having hyperlipidaemia was an independent risk factor, but being overweight or having hyperlipidaemia alone was not. The combination of hyperuricaemia, being overweight and hyperlipidaemia further increased the risk of CSA-AKI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperuricemia / Lesión Renal Aguda / Procedimientos Quirúrgicos Cardíacos / Hiperlipidemias Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperuricemia / Lesión Renal Aguda / Procedimientos Quirúrgicos Cardíacos / Hiperlipidemias Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido