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Latent profiles of autism symptoms in children and adolescents with Down syndrome.
Fidler, D J; Prince, M A; Van Deusen, K; Esbensen, A J; Thurman, A J; Abbeduto, L; Patel, L; Mervis, C; Schworer, E K; Lee, N R; Edgin, J O; Hepburn, S; Davis, S; Daunhauer, L A.
Afiliación
  • Fidler DJ; Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA.
  • Prince MA; Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA.
  • Van Deusen K; Department of Psychology, Colorado State University, Fort Collins, CO, USA.
  • Esbensen AJ; Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA.
  • Thurman AJ; Department of Pediatrics, Cincinnati Children's Hospital Medical Campus, Cincinnati, OH, USA.
  • Abbeduto L; Department of Psychiatry, MIND Institute, University of California - Davis Health, Sacramento, CA, USA.
  • Patel L; Department of Psychiatry, MIND Institute, University of California - Davis Health, Sacramento, CA, USA.
  • Mervis C; Department of Psychiatry, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA.
  • Schworer EK; Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY, USA.
  • Lee NR; Department of Pediatrics, Cincinnati Children's Hospital Medical Campus, Cincinnati, OH, USA.
  • Edgin JO; Department of Psychology, Drexel University, Philadelphia, PA, USA.
  • Hepburn S; Sonoran University Center for Excellence in Developmental Disabilities, University of Arizona, Tucson, AZ, USA.
  • Davis S; Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA.
  • Daunhauer LA; Department of Psychology, Colorado State University, Fort Collins, CO, USA.
J Intellect Disabil Res ; 66(3): 265-281, 2022 03.
Article en En | MEDLINE | ID: mdl-34984734
BACKGROUND: Down syndrome (DS) is associated with elevated rates of autism spectrum disorder (ASD) and autism symptomatology. To better characterise heterogeneity in ASD symptomatology in DS, profiles of caregiver-reported ASD symptoms were modelled for children and adolescents with DS. METHODS: Participants (n = 125) were recruited through several multi-site research studies on cognition and language in DS. Using the Social Responsiveness Scale-2 (SRS-2; Constantino and Gruber 2012), two latent profile analyses (LPA) were performed, one on the broad composite scores of social communication and interaction and restricted interests and repetitive behaviour, and a second on the four social dimensions of social communication, social motivation, social awareness, and social cognition. RESULTS: A three-profile model was the best fit for both analyses, with each analysis yielding a low ASD symptom profile, an elevated or mixed ASD symptom profile and a high ASD symptom profile. Associations were observed between profile probability scores and IQ, the number of co-occurring biomedical conditions reported, sex, and SRS-2 form. CONCLUSIONS: Characterising heterogeneity in ASD symptom profiles can inform more personalised supports in this population, and implications for potential therapeutic approaches for individuals with DS are discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Síndrome de Down / Trastorno del Espectro Autista Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adolescent / Child / Humans Idioma: En Revista: J Intellect Disabil Res Asunto de la revista: TRANSTORNOS MENTAIS Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Síndrome de Down / Trastorno del Espectro Autista Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adolescent / Child / Humans Idioma: En Revista: J Intellect Disabil Res Asunto de la revista: TRANSTORNOS MENTAIS Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido