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Lipid Droplet-a New Target in Ischemic Heart Disease.
Guo, Xiaoying; Shi, Qi; Zhang, Wanqin; Qi, Zhongwen; Lv, Hao; Man, Fujing; Xie, Yingyu; Zhu, Yaping; Zhang, Junping.
Afiliación
  • Guo X; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Shi Q; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
  • Zhang W; Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Qi Z; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Lv H; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
  • Man F; Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Xie Y; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • Zhu Y; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
  • Zhang J; Tianjin University of Traditional Chinese Medicine, Tianjin, China.
J Cardiovasc Transl Res ; 15(4): 730-739, 2022 08.
Article en En | MEDLINE | ID: mdl-34984637
Lipid droplet (LD) is a kind of subcellular organelle, which originates from the endoplasmic reticulum (ER). LDs can move flexibly between other organelles and store energy in the cells. In recent years, LDs and lipid droplet-associated proteins have attracted added attention at home and abroad, especially in cardiovascular diseases. Cardiovascular diseases, especially ischemic heart disease (IHD), have always been the focus of attention because of their high morbidity and mortality. Atherosclerosis and myocardial remodeling are two important pathologic processes of IHD, and LDs and other organelles are involved in the development of the disease. The interaction between LDs and ER is involved in the formation of foam cells in atherosclerosis. And LDs, mitochondria, and lysosomes also affect the remodeling of cardiomyocytes by affecting ROS production and regulating PI3K/AKT pathways. In this article, we will review the role of LDs in IHD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Isquemia Miocárdica / Aterosclerosis Límite: Humans Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Isquemia Miocárdica / Aterosclerosis Límite: Humans Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos