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Can maternal exposure to tamoxifen compromise sperm and behavioural parameters of male rat offspring?
de Matos Manoel, Beatriz; da Silva Moreira, Suyane; Zampieri, Gabriela Morelli; Machado Pinheiro, Luísa; Jorge, Bárbara Campos; Casali Reis, Ana Carolina; Leite Kassuya, Cândida Aparecida; Arena, Arielle Cristina.
Afiliación
  • de Matos Manoel B; Faculty of Health Sciences, Universidade Federal da Grande Dourados - UFGD, Dourados, MS, Brazil.
  • da Silva Moreira S; Departamet of Structural and Functional Biology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, SP, Brazil.
  • Zampieri GM; Departamet of Structural and Functional Biology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, SP, Brazil.
  • Machado Pinheiro L; Departamet of Structural and Functional Biology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, SP, Brazil.
  • Jorge BC; Departamet of Structural and Functional Biology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, SP, Brazil.
  • Casali Reis AC; Departamet of Structural and Functional Biology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, SP, Brazil.
  • Leite Kassuya CA; Faculty of Health Sciences, Universidade Federal da Grande Dourados - UFGD, Dourados, MS, Brazil.
  • Arena AC; Departamet of Structural and Functional Biology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, SP, Brazil; Center of Toxicological Assistance (CEATOX), Institute of Biosciences of Botucatu, Univ. Estadual Paulista - Botucatu (UNESP), São Paulo, Brazil. Elect
Reprod Toxicol ; 108: 1-9, 2022 03.
Article en En | MEDLINE | ID: mdl-34974146
Tamoxifen, a selective non-steroidal estrogen receptor modulator, is the standard adjuvant endocrine treatment for breast cancer. Since information on the risk of using tamoxifen during pregnancy is still scarce, this study evaluated whether the in utero and lactational treatment with this drug could compromise reproductive and behavioural parameters in male offspring. Pregnant Wistar rats were exposed to three doses of tamoxifen (0.12; 0.6; 3 µg/kg), by gavage, from gestational day 15 to lactational day 20. Tamoxifen exposure did not alter the anogenital distance in the male offspring; however, there was a significant increase in the body weight in the 0.12 µg/kg dose and a decrease in the 0.6 µg/kg dose. The male offspring treated with the highest dose exhibited a delay in the onset of puberty, evidenced by an increase in the age of preputial separation. Regarding sperm parameters, there was an increase in the sperm count in the cauda epididymis in the intermediate and highest dose groups, in addition to an increase in the number of static sperm and a decrease in the progressive sperm in the same groups. Moreover, an increase in the number of hyperplasia of the epithelial clear cells was observed in the epididymis. In conclusion, the present study demonstrated that maternal exposure to tamoxifen compromised the installation of puberty of the male offspring and the maturation of the epididymis, affecting sperm storage and motility in the adult life.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Espermatozoides / Tamoxifeno / Conducta Animal / Moduladores Selectivos de los Receptores de Estrógeno Límite: Animals / Pregnancy Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Espermatozoides / Tamoxifeno / Conducta Animal / Moduladores Selectivos de los Receptores de Estrógeno Límite: Animals / Pregnancy Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos