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Red blood cell distribution width in glioblastoma.
Kelly, Patrick D; Dambrino, Robert J; Guidry, Bradley S; Tang, Alan R; Stewart, Thomas G; Mistry, Akshitkumar; Morone, Peter J; Chambless, Lola B.
Afiliación
  • Kelly PD; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, United States.
  • Dambrino RJ; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address: Rob.dambrino@vumc.org.
  • Guidry BS; Vanderbilt University School of Medicine, Nashville, TN, United States.
  • Tang AR; Vanderbilt University School of Medicine, Nashville, TN, United States.
  • Stewart TG; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Mistry A; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, United States.
  • Morone PJ; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, United States.
  • Chambless LB; Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, United States.
Clin Neurol Neurosurg ; 213: 107096, 2022 02.
Article en En | MEDLINE | ID: mdl-34973653
INTRODUCTION: Glioblastoma (GBM) is the most common and deadly adult brain tumor. Red blood cell distribution width (RDW) has been found in non-central nervous system neoplasms to be associated with survival. This study aims to assess the prognostic value of pre-operative RDW and trends in RDW over time during the disease course. METHODS: This single-institution retrospective cohort study identified patients ≥ 18 years old with pathology-proved glioblastoma treated between April 2003-May 2017 from an institutional database. A Cox proportional hazards model was developed using known prognostic clinical variables to predict overall survival time; a second model incorporating continuously valued RDW was then created. The additional prognostic value of RDW was assessed with a joint model F-test. The variation of RDW-CV over time was evaluated with linear mixed model of RDW. A post-hoc exploratory analysis was performed to assess the trend in RDW lab value leading up to time of death. RESULTS: 346 adult GBM patients were identified; complete survival data was available for all patients. The addition of RDW to the multivariable Cox proportional hazards model did not increase prognostic value. There was an upward trend in RDW throughout the post-operative disease course. In a post-hoc analysis, there was an upward trend in RDW leading up to the time of death. CONCLUSION: Although RDW has been prognostic of survival for many inflammatory, prothrombotic, and neoplastic diseases, pre-operative RDW was not associated with overall survival in GBM patients. RDW trended upwards throughout the disease course, suggesting possible systemic inflammatory effects of either glioblastoma or treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glioblastoma Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Humans Idioma: En Revista: Clin Neurol Neurosurg Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glioblastoma Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Humans Idioma: En Revista: Clin Neurol Neurosurg Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos