Cutaneous collagenous vasculopathy: A report of three cases.

Grossman, Marc E; Cohen, Marc; Ravits, Margaret; Blume, Ralph; Magro, Cynthia M

Grossman, Marc E; Cohen, Marc; Ravits, Margaret; Blume, Ralph; Magro, Cynthia M.

Afiliación

Grossman ME; Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA.
Cohen M; Department of Dermatology, Hofstra/Northwell Donald and Barbara Zucker School of Medicine, New Hyde Park, New York, USA.
Ravits M; State University of New York Downstate College of Medicine, Brooklyn, New York, USA.
Blume R; Department of Dermatology, Columbia University, New York, New York, USA.
Magro CM; Department of Dermatology, Columbia University, New York, New York, USA.

J Cutan Pathol ; 49(5): 491-495, 2022 May.

Article en En | MEDLINE | ID: mdl-34961963

RESUMEN

Cutaneous collagenous vasculopathy is a rare pauci-inflammatory, superficial, cutaneous vasculopathy characterized by progressive fine-branching telangiectasias clinically, while light microscopically one observes dilated venules and capillaries within the superficial dermis exhibiting excessive Type IV collagen within the vessel wall. We present three cases of collagenous vasculopathy. Two cases were associated with certain autoimmune stigmata, including a positive serologic anti-endothelial cell antibody assay and positive lupus anticoagulant in one, while the third case had positive anti-ribonucleoprotein (RNP) antibodies. The latter case was associated with chronic hydroxyurea therapy for an underlying myeloproliferative disorder. We explore the role of immune- and non-immune-based endothelial cell injury in the pathogenesis of collagenous vasculopathy.

Asunto(s)

Enfermedades Cutáneas Vasculares; Telangiectasia; Humanos; Piel/patología; Enfermedades Cutáneas Vasculares/patología; Telangiectasia/patología; Venas/patología

Palabras clave

biopsy; collagen; skin; telangiectasias; vasculopathy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Telangiectasia / Enfermedades Cutáneas Vasculares Límite: Humans Idioma: En Revista: J Cutan Pathol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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