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The Effect of Superoxide Dismutase on Inhibition of Acute Kidney Injury Induced by Sepsis Based on Kidney Tissue Histology and Murine Sepsis Score.
Ismy, Jufitriani; Syukri, Maimun; Emril, Dessy R; Sekarwana, Nanan; Ismy, Jufriady; Suhanda, Rachmad.
Afiliación
  • Ismy J; Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.
  • Syukri M; Department of Pediatrics, Faculty of Medicine, Universitas Syiah Kuala, General Hospital dr. Zainoel Abidin, Banda Aceh 23111, Indonesia.
  • Emril DR; Department of Internal Medicine, Universitas Syiah Kuala, General Hospital dr. Zainoel Abidin, Banda Aceh 23111, Indonesia.
  • Sekarwana N; Department of Neurology, Faculty of Medicine, Universitas Syiah Kuala, General Hospital dr. Zainoel Abidin, Banda Aceh 23111, Indonesia.
  • Ismy J; Department of Pediatrics, Faculty of Medicine, Universitas Islam Bandung, Bandung 40161, Indonesia.
  • Suhanda R; Departement of Surgery, Urology Division Faculty of Medicine, Universitas Syiah Kuala, General Hospital dr. Zainoel Abidin, Banda Aceh 23111, Indonesia.
ScientificWorldJournal ; 2021: 1827296, 2021.
Article en En | MEDLINE | ID: mdl-34955689
Sepsis is one of the leading causes contributing to the incidence of acute kidney injury (AKI). Oxidative stress can be used as the main approach against sepsis-induced AKI. One of the primary antioxidants that plays a role in warding off oxidative stress is superoxide dismutase (SOD). This research aimed to observe the effect of antioxidant SOD in inhibiting sepsis in AKI based on kidney tissue histopathology. The research method was an experimental laboratory with a post-test-only control group design. Twenty-five adult male rats aged 12-16 weeks, weighing between 200 and 250 g, were randomly divided into five groups: Group I, as a positive control, where rats were injected with lipopolysaccharides (LPS); Group II, as a negative control; Group III, as treatment 1, where rats were injected with LPS and administered orally with SOD (Glisodin®) 250 IU daily; Group IV, as treatment 2, where rats were injected with LPS and administered orally with SOD (Glisodin®) 500 IU daily; and Group V, as treatment 2, where rats were injected with LPS and administered orally with SOD (Glisodin®) 1000 IU daily. Rats were administered with SOD (Glisodin®) by oral gavage with a flexible feeding tube for 16 weeks, given once daily in the morning, and then injected with LPS of 10 mg/kg body weight. Glisodin SOD had a significant effect on murine sepsis score (MSS). MSS influenced the tubular injury score linearly. We conclude that the optimal dose of SOD at 1000 IU for inhibiting sepsis-induced AKI incidence is compared to SOD at a dose of 250 and 500 IU. The antioxidant effect of SOD can prevent sepsis-induced AKI with oxidative stress events.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Superóxido Dismutasa / Sepsis / Lesión Renal Aguda / Riñón / Antioxidantes Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: ScientificWorldJournal Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Superóxido Dismutasa / Sepsis / Lesión Renal Aguda / Riñón / Antioxidantes Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: ScientificWorldJournal Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Estados Unidos