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[Evaluation of screening strategies of multidrug-resistant tuberculosis among pulmonary tuberculosis patients of the different risk levels].
Chen, H J; Zheng, X B; Wang, Y; Li, J L; Xu, B.
Afiliación
  • Chen HJ; Institute of Tuberculosis Prevention and Control, Guizhou Center for Disease Control and Prevention, Guiyang 550004, China.
  • Zheng XB; Key Laboratory of Public Health Safety of the Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China.
  • Wang Y; School of Medicine and Health Management, Guizhou Medical University, Guiyang 550001, China.
  • Li JL; Institute of Tuberculosis Prevention and Control, Guizhou Center for Disease Control and Prevention, Guiyang 550004, China.
  • Xu B; School of Medicine and Health Management, Guizhou Medical University, Guiyang 550001, China.
Zhonghua Liu Xing Bing Xue Za Zhi ; 42(12): 2164-2169, 2021 Dec 10.
Article en Zh | MEDLINE | ID: mdl-34954981
Objective: To evaluate the detection of MDR-TB and XDR-TB patients and to provide evidence for further improvement of MDR-TB and XDR-TB screening strategy. Methods: Patients who were under drug resistance surveillance, registered and reported by the TB Management Information System of the Chinese Disease Prevention and Control Information System from 2012 to 2019 and resided in Guizhou province were retrospectively analyzed. The contribution of five high-risk subgroups to detection of MDR/XDR-TB were evaluated using population attributable risk proportion (PARP). Results: Of the 18 506 cases under drug resistance surveillance, patients who were male, aged between 25 and 54 years, with drug-resistant TB or with MDR/XDR-TB accounted for 68.65% (12 705/18 506), 47.69% (8 826/18 506), 15.90% (2 943/18 506) or 5.42% (1 003/18 506), respectively. Five high-risk subgroups made significant contributions to the detection of MDR/XDR-TB with a PARP of 57.00%. Specifically, the PARP were 21.70%, 19.49%, 11.90% and 2.30% for patients that were relapse and return, failed initial treatment, chronic/retreatment failure and smear-positive at the end of the second or third month, respectively. The detection rate of MDR/XDR-TB in high-risk groups was 15.89% (578/3 637) while in low-risk groups was 2.86% (425/14 869). Conclusions: Number of patients under drug resistance surveillance and the detection of MDR/XDR-TB trended to increase in Guizhou province from 2012 to 2019. The detection rate of MDR/XDR-TB in high-risk groups was higher than low-risk groups.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis Pulmonar / Tuberculosis Resistente a Múltiples Medicamentos / Tuberculosis Extensivamente Resistente a Drogas / Mycobacterium tuberculosis Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Humans / Male / Middle aged Idioma: Zh Revista: Zhonghua Liu Xing Bing Xue Za Zhi Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis Pulmonar / Tuberculosis Resistente a Múltiples Medicamentos / Tuberculosis Extensivamente Resistente a Drogas / Mycobacterium tuberculosis Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Humans / Male / Middle aged Idioma: Zh Revista: Zhonghua Liu Xing Bing Xue Za Zhi Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: China