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Baseline Neuroimaging Predicts Decline to Dementia From Amnestic Mild Cognitive Impairment.
Gullett, Joseph M; Albizu, Alejandro; Fang, Ruogu; Loewenstein, David A; Duara, Ranjan; Rosselli, Monica; Armstrong, Melissa J; Rundek, Tatjana; Hausman, Hanna K; Dekosky, Steven T; Woods, Adam J; Cohen, Ronald A.
Afiliación
  • Gullett JM; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States.
  • Albizu A; Department of Neuroscience, University of Florida, Gainesville, FL, United States.
  • Fang R; Clayton J. Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
  • Loewenstein DA; Center for Cognitive Neuroscience and Aging, University of Miami Miller School of Medicine, Miami, FL, United States.
  • Duara R; Department of Neurology, University of Florida, Gainesville, FL, United States.
  • Rosselli M; Department of Psychology, Florida Atlantic University, Davie, FL, United States.
  • Armstrong MJ; Department of Neurology, University of Florida, Gainesville, FL, United States.
  • Rundek T; Evelyn F. McKnight Brain Institute, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States.
  • Hausman HK; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States.
  • Dekosky ST; Department of Neurology, University of Florida, Gainesville, FL, United States.
  • Woods AJ; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States.
  • Cohen RA; Department of Neuroscience, University of Florida, Gainesville, FL, United States.
Front Aging Neurosci ; 13: 758298, 2021.
Article en En | MEDLINE | ID: mdl-34950021
Background and Objectives: Prediction of decline to dementia using objective biomarkers in high-risk patients with amnestic mild cognitive impairment (aMCI) has immense utility. Our objective was to use multimodal MRI to (1) determine whether accurate and precise prediction of dementia conversion could be achieved using baseline data alone, and (2) generate a map of the brain regions implicated in longitudinal decline to dementia. Methods: Participants meeting criteria for aMCI at baseline (N = 55) were classified at follow-up as remaining stable/improved in their diagnosis (N = 41) or declined to dementia (N = 14). Baseline T1 structural MRI and resting-state fMRI (rsfMRI) were combined and a semi-supervised support vector machine (SVM) which separated stable participants from those who decline at follow-up with maximal margin. Cross-validated model performance metrics and MRI feature weights were calculated to include the strength of each brain voxel in its ability to distinguish the two groups. Results: Total model accuracy for predicting diagnostic change at follow-up was 92.7% using baseline T1 imaging alone, 83.5% using rsfMRI alone, and 94.5% when combining T1 and rsfMRI modalities. Feature weights that survived the p < 0.01 threshold for separation of the two groups revealed the strongest margin in the combined structural and functional regions underlying the medial temporal lobes in the limbic system. Discussion: An MRI-driven SVM model demonstrates accurate and precise prediction of later dementia conversion in aMCI patients. The multi-modal regions driving this prediction were the strongest in the medial temporal regions of the limbic system, consistent with literature on the progression of Alzheimer's disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Aging Neurosci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Aging Neurosci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza