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A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy.
Zhang, Yun-Chang; Zeng, Pei-Yu; Ma, Zhi-Qiang; Xu, Zi-Yue; Wang, Ze-Kun; Guo, Beibei; Yang, Feng; Li, Zhan-Ting.
Afiliación
  • Zhang YC; School of Pharmacy, Naval Medical University, Shanghai, China.
  • Zeng PY; School of Pharmacy, Naval Medical University, Shanghai, China.
  • Ma ZQ; School of Pharmacy, Naval Medical University, Shanghai, China.
  • Xu ZY; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, China.
  • Wang ZK; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, China.
  • Guo B; School of Pharmacy, Naval Medical University, Shanghai, China.
  • Yang F; School of Pharmacy, Naval Medical University, Shanghai, China.
  • Li ZT; Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, China.
Drug Deliv ; 29(1): 1-9, 2022 Dec.
Article en En | MEDLINE | ID: mdl-34949133
Chemotherapy is one of the main ways to treat breast cancer clinically. However, the multidrug resistance to anti-tumor drugs limits their clinical use. To overcome these drawbacks, the development of drug delivery systems (DDSs) has attracted more and more attention in cancer therapy. At present, the preparation and purification process are complicated for many reported DDSs, while the clinic calls for new DDSs that are more convenient for preparation. Here a new pH-responsive supramolecular organic framework drug delivery complex loading doxorubicin (DOX) is fabricated. Anti-tumor activity of the system in vitro was investigated by cell cytotoxicity, uptake assay, and cell apoptosis analysis. The anti-tumor activity in vivo was investigated by inspecting nude mice body weight, tumor volume and weight, also a preliminary mechanism probe was conducted by HE and TUNEL staining. The DOX@SOF displayed high stability, good biocompatibility and pH-regulated drug release. At acid condition, the hydrazone bonds would be broken, which result in the dissociation of SOF, and then the drugs would be released from the system. Furthermore, DOX@SOF enhanced cellular internalization. Both in vitro and in vivo experiments reflected that DOX@SOF could enhance the anti-tumor activity of DOX. for the MCF-7/ADR tumor cells and tumors. This study provides a highly efficient strategy to prepare a stimulus-responsive supramolecular drug delivery complex for the treatment of drug-resistant cancer, the results presented inspiring scientific interests in exploring new drug delivery strategies and reversing multi-drug resistance for clinical chemotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Portadores de Fármacos / Doxorrubicina / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Drug Deliv Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Portadores de Fármacos / Doxorrubicina / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: Drug Deliv Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido