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Incidence and risk of cancer among multiple sclerosis patients: A matched population-based cohort study.
Bosco-Lévy, Pauline; Foch, Caroline; Grelaud, Angela; Sabidó, Meritxell; Lacueille, Clémentine; Jové, Jérémy; Boutmy, Emmanuelle; Blin, Patrick.
Afiliación
  • Bosco-Lévy P; Bordeaux PharmacoEpi, University of Bordeaux, National Institute of Health and Medical Research CIC-P1401, Bordeaux, France.
  • Foch C; Department of Epidemiology, Merck Healthcare, Darmstadt, Germany.
  • Grelaud A; Bordeaux PharmacoEpi, University of Bordeaux, National Institute of Health and Medical Research CIC-P1401, Bordeaux, France.
  • Sabidó M; Department of Epidemiology, Merck Healthcare, Darmstadt, Germany.
  • Lacueille C; Bordeaux PharmacoEpi, University of Bordeaux, National Institute of Health and Medical Research CIC-P1401, Bordeaux, France.
  • Jové J; Bordeaux PharmacoEpi, University of Bordeaux, National Institute of Health and Medical Research CIC-P1401, Bordeaux, France.
  • Boutmy E; Department of Epidemiology, Merck Healthcare, Darmstadt, Germany.
  • Blin P; Bordeaux PharmacoEpi, University of Bordeaux, National Institute of Health and Medical Research CIC-P1401, Bordeaux, France.
Eur J Neurol ; 29(4): 1091-1099, 2022 04.
Article en En | MEDLINE | ID: mdl-34936169
BACKGROUND AND PURPOSE: Studies have not yet found conclusive results on the risk of cancer in patients with multiple sclerosis (MS). This study aimed to compare the incidence of all cancers and of specific types of cancer between MS patients and the general population by age and by sex. METHODS: All prevalent MS patients identified between 2008 and 2014 in the nationwide French health care database (Système National des Données de Santé) and without history of malignancy were included in a cohort study and followed up until cancer occurrence, date of death, or 31 December 2015, whichever came first. MS patients were matched based on sex and year of birth to non-MS controls from the general population without cancer before index date. Incidence rate was reported per 100,000 person-years (PY), and risk of cancer was estimated by type of cancer, age, and sex using a Cox model (hazard ratio [HR] and its 95% confidence interval [CI]). RESULTS: Overall, 576 cancers per 100,000 PY were observed in MS patients versus 424 per 100,000 PY in the control population. The risk of cancer was higher among MS patients than among population controls whether considered overall (HR = 1.36, 95% CI = 1.29-1.43) or for prostate (HR = 2.08, 95% CI = 1.68-2.58), colorectal and anal (HR = 1.35, 95% CI = 1.16-1.58), trachea, bronchus, and lung (HR = 2.36, 95% CI = 1.96-2.84), and to a lesser extent, breast cancer (HR = 1.12, 95% CI = 1.03-1.23). CONCLUSIONS: MS patients were associated with increased risk of cancer compared to population controls.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Múltiple / Neoplasias Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Múltiple / Neoplasias Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido