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[Advances in the role of extracellular histones in the inflammatory process of liver injury].
Shi, C X; Wang, Y; Chen, Q; Jiao, F Z; Pei, M H; Gong, Z J.
Afiliación
  • Shi CX; Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Wang Y; Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Chen Q; Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Jiao FZ; Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Pei MH; Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, China.
  • Gong ZJ; Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Zhonghua Gan Zang Bing Za Zhi ; 29(11): 1124-1127, 2021 Nov 20.
Article en Zh | MEDLINE | ID: mdl-34933438
Histones are important structural proteins of chromatin in the nucleus, which can regulate gene transcription, and can be released from the nucleus to the outside of the cell under injury and inflammatory stimulations, thereby causing cytotoxicity and immune stimulation, and aggravating tissue damage. Extracellular histones are involved in the occurrence and development of many diseases, including sepsis, autoimmune diseases, liver injury, and acute lung injury. Therefore, its application not only can be used as a body's biomarker of inflammation, but also it is expected to become a molecular target for the treatment of diseases. This article reviews the role of extracellular histones in the inflammatory process of liver injury.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Histonas Límite: Humans Idioma: Zh Revista: Zhonghua Gan Zang Bing Za Zhi Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Histonas Límite: Humans Idioma: Zh Revista: Zhonghua Gan Zang Bing Za Zhi Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: China