Linkage studies of HLA and rheumatoid arthritis in multicase families.

Walker, D J; Burn, J; Griffiths, I D; Roberts, D F; Stephenson, A M

Walker, D J; Burn, J; Griffiths, I D; Roberts, D F; Stephenson, A M.

Arthritis Rheum ; 30(1): 31-5, 1987 Jan.

Article en En | MEDLINE | ID: mdl-3493007

RESUMEN

The linkage of rheumatoid arthritis (RA) to the HLA-DR locus was investigated in 17 families with multiple cases of RA. Log odds scores were computed using the Liped program; sibship associations were examined by 2 methods. The results showed a trend toward linkage which was short of significance. The results were similar for patients with classic or definite RA, with or without the inclusion of probable RA patients. The finding of strong association and weak linkage would suggest that it is DR4, itself, that is important in RA.

Asunto(s)

Artritis Reumatoide/genética; Ligamiento Genético; Antígenos HLA/genética; Artritis Reumatoide/inmunología; Susceptibilidad a Enfermedades; Genes; Antígenos HLA-DR/análisis; Antígeno HLA-DR4; Haplotipos; Humanos; Linaje

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Antígenos HLA / Ligamiento Genético Límite: Humans Idioma: En Revista: Arthritis Rheum Año: 1987 Tipo del documento: Article Pais de publicación: Estados Unidos

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