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Soluble LRIG2 is a potential biomarker for type 2 diabetes mellitus.
Kim, Ji Min; Joung, Kyong Hye; Lee, Jun Choul; Choung, Sorim; Kang, Seon Mee; Kim, Hyun Jin; Ku, Bon Jeong.
Afiliación
  • Kim JM; Department of Endocrinology, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.
  • Joung KH; Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
  • Lee JC; Department of Endocrinology, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.
  • Choung S; Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
  • Kang SM; Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
  • Kim HJ; Department of Medical Science, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
  • Ku BJ; Department of Internal Medicine, Busan Paik Hospital, College of Medicine, Inje University, Busan, South Korea.
Ann Transl Med ; 9(21): 1612, 2021 Nov.
Article en En | MEDLINE | ID: mdl-34926656
BACKGROUND: Early diagnosis and treatment of type 2 diabetes can delay the onset of microvascular and macrovascular complications. Therefore, the identification of a novel biomarker for diagnosing diabetes is necessary. In the present study, the role of serum soluble leucine-rich repeats and immunoglobulin like domains 2 (sLRIG2) was investigated as a diagnostic biomarker of type 2 diabetes. METHODS: A total of 240 subjects with newly diagnosed type 2 diabetes (n=80), prediabetes (n=80), or normal glucose tolerance (NGT; n=80) were included in this study. The fasting serum sLRIG2 level was measured using a quantitative sandwich enzyme immunoassay technique with an enzyme-linked immunosorbent assay (ELISA). Serum sLRIG2 levels were compared among the three groups, and the associations of serum sLRIG2 levels with clinical variables were investigated. RESULTS: Serum sLRIG2 levels were significantly higher in subjects with type 2 diabetes (16.7±8.0 ng/mL) than in subjects without diabetes (NGT group: 12.3±5.3 ng/mL, P<0.001; prediabetes group: 13.2±5.8 ng/mL, P=0.002). Glycosylated hemoglobin (HbA1c: r=0.378, P<0.001) and blood glucose (fasting: r=0.421, P<0.001; 2-hour postprandial: r=0.433, P<0.001) correlated more strongly with sLRIG2 than any other clinical variables. CONCLUSIONS: The serum sLRIG2 levels correlated with glucose parameters; thus, sLRIG2 might be a novel diagnostic biomarker for type 2 diabetes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Screening_studies Idioma: En Revista: Ann Transl Med Año: 2021 Tipo del documento: Article Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Screening_studies Idioma: En Revista: Ann Transl Med Año: 2021 Tipo del documento: Article Pais de publicación: China