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Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease.
Woon, Choy Ker; Hui, Wong Kah; Abas, Razif; Haron, Muhammad Huzaimi; Das, Srijit; Lin, Teoh Seong.
Afiliación
  • Woon CK; Department of Anatomy, Faculty of Medicine, Universiti Teknologi MARA, 47000 Selangor, Malaysia.
  • Hui WK; Department of Anatomy, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
  • Abas R; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Selangor, Malaysia.
  • Haron MH; Department of Pharmacology, Faculty of Medicine, Universiti Teknologi MARA, 47000 Selangor, Malaysia.
  • Das S; Department of Human and Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khoud, Muscat 123, Sultanate of Oman.
  • Lin TS; Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia.
Curr Neuropharmacol ; 20(8): 1498-1518, 2022.
Article en En | MEDLINE | ID: mdl-34923947
Alzheimer's disease (AD) affects the elderly and is characterized by progressive neurodegeneration caused by different pathologies. The most significant challenges in treating AD include the inability of medications to reach the brain because of its poor solubility, low bioavailability, and the presence of the blood-brain barrier (BBB). Additionally, current evidence suggests the disruption of BBB plays an important role in the pathogenesis of AD. One of the critical challenges in treating AD is the ineffective treatments and their severe adverse effects. Nanotechnology offers an alternative approach to facilitate the treatment of AD by overcoming the challenges in drug transport across the BBB. Various nanoparticles (NP) loaded with natural products were reported to aid in drug delivery for the treatment of AD. The nano-sized entities of NP are great platforms for incorporating active materials from natural products into formulations that can be delivered effectively to the intended action site without compromising the material's bioactivity. The review highlights the applications of medicinal plants, their derived components, and various nanomedicinebased approaches for the treatment of AD. The combination of medicinal plants and nanotechnology may lead to new theragnostic solutions for the treatment of AD in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Nanopartículas / Enfermedad de Alzheimer Límite: Aged / Humans Idioma: En Revista: Curr Neuropharmacol Año: 2022 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Emiratos Árabes Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Productos Biológicos / Nanopartículas / Enfermedad de Alzheimer Límite: Aged / Humans Idioma: En Revista: Curr Neuropharmacol Año: 2022 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Emiratos Árabes Unidos