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Relationships between correlated spikes, oxygen and LFP in the resting-state primate.
Li, Jingfeng M; Acland, Benjamin T; Brenner, Alexander S; Bentley, William J; Snyder, Lawrence H.
Afiliación
  • Li JM; Department of Neuroscience, Washington University School of Medicine, 660 S Euclid Ave, Box 8108, St Louis, MO 63110, USA.
  • Acland BT; Department of Neuroscience, Washington University School of Medicine, 660 S Euclid Ave, Box 8108, St Louis, MO 63110, USA.
  • Brenner AS; Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA.
  • Bentley WJ; Department of Neuroscience, Washington University School of Medicine, 660 S Euclid Ave, Box 8108, St Louis, MO 63110, USA.
  • Snyder LH; Department of Neuroscience, Washington University School of Medicine, 660 S Euclid Ave, Box 8108, St Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA. Electronic address: larry@eye-hand.wustl.edu.
Neuroimage ; 247: 118728, 2022 02 15.
Article en En | MEDLINE | ID: mdl-34923136
Resting-state functional MRI (rsfMRI) provides a view of human brain organization based on correlation patterns of blood oxygen level dependent (BOLD) signals recorded across the whole brain. The neural basis of resting-state BOLD fluctuations and their correlation remains poorly understood. We simultaneously recorded oxygen level, spikes, and local field potential (LFP) at multiple sites in awake, resting monkeys. Following a spike, the average local oxygen and LFP voltage responses each resemble a task-driven BOLD response, with LFP preceding oxygen by 0.5 s. Between sites, features of the long-range correlation patterns of oxygen, LFP, and spikes are similar to features seen in rsfMRI. Most of the variance shared between sites lies in the infraslow frequency band (0.01-0.1 Hz) and in the infraslow envelope of higher-frequency bands (e.g. gamma LFP). While gamma LFP and infraslow LFP are both strong correlates of local oxygen, infraslow LFP explains significantly more of the variance shared between correlated oxygen signals than any other electrophysiological signal. Together these findings are consistent with a causal relationship between infraslow LFP and long-range oxygen correlations in the resting state.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Primates / Descanso / Encéfalo Límite: Animals Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Primates / Descanso / Encéfalo Límite: Animals Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos