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Identification of DNA methylation biomarkers with potential to predict response to neoadjuvant chemotherapy in triple-negative breast cancer.
Meyer, Braydon; Clifton, Samuel; Locke, Warwick; Luu, Phuc-Loi; Du, Qian; Lam, Dilys; Armstrong, Nicola J; Kumar, Beena; Deng, Niantao; Harvey, Kate; Swarbrick, Alex; Ganju, Vinod; Clark, Susan J; Pidsley, Ruth; Stirzaker, Clare.
Afiliación
  • Meyer B; Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.
  • Clifton S; Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.
  • Locke W; Molecular Diagnostics Solutions, CSIRO Health and Biosecurity, New South Wales, North Ryde, 2113, Australia.
  • Luu PL; Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.
  • Du Q; St. Vincent's Clinical School, UNSW Australia, Sydney, NSW, 2010, Australia.
  • Lam D; Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.
  • Armstrong NJ; St. Vincent's Clinical School, UNSW Australia, Sydney, NSW, 2010, Australia.
  • Kumar B; Epigenetics Research Laboratory, Genomics and Epigenetics Theme, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia.
  • Deng N; Department of Mathematics and Statistics, Curtin University, Perth, WA, 6103, Australia.
  • Harvey K; Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
  • Swarbrick A; Monash Health Pathology, Monash Health, Victoria, 3168, Australia.
  • Ganju V; Monash University, Melbourne, VIC, 3168, Australia.
  • Clark SJ; St. Vincent's Clinical School, UNSW Australia, Sydney, NSW, 2010, Australia.
  • Pidsley R; Cancer Research Theme, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.
  • Stirzaker C; Cancer Research Theme, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.
Clin Epigenetics ; 13(1): 226, 2021 12 18.
Article en En | MEDLINE | ID: mdl-34922619
Neoadjuvant chemotherapy (NAC) is used to treat triple-negative breast cancer (TNBC) prior to resection. Biomarkers that accurately predict a patient's response to NAC are needed to individualise therapy and avoid chemotoxicity from unnecessary chemotherapy. We performed whole-genome DNA methylation profiling on diagnostic TNBC biopsy samples from the Sequential Evaluation of Tumours Undergoing Preoperative (SETUP) NAC study. We found 9 significantly differentially methylated regions (DMRs) at diagnosis which were associated with response to NAC. We show that 4 of these DMRs are associated with TNBC overall survival (P < 0.05). Our results highlight the potential of DNA methylation biomarkers for predicting NAC response in TNBC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Terapia Neoadyuvante / Biomarcadores Farmacológicos / Neoplasias de la Mama Triple Negativas Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Epigenetics Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Terapia Neoadyuvante / Biomarcadores Farmacológicos / Neoplasias de la Mama Triple Negativas Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Epigenetics Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania