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exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids.
Lai, Hongyan; Li, Yuchen; Zhang, Hena; Hu, Jia; Liao, Jiatao; Su, Ying; Li, Qin; Chen, Bing; Li, Caiping; Wang, Zhen; Li, Yan; Wang, Jialei; Meng, Zhiqiang; Huang, Zhaohui; Huang, Shenglin.
Afiliación
  • Lai H; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, Chin
  • Li Y; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Zhang H; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, Chin
  • Hu J; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Liao J; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, Chin
  • Su Y; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Li Q; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, Chin
  • Chen B; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Li C; Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Wang Z; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Li Y; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, Chin
  • Wang J; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Meng Z; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, Chin
  • Huang Z; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  • Huang S; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, Chin
Nucleic Acids Res ; 50(D1): D118-D128, 2022 01 07.
Article en En | MEDLINE | ID: mdl-34918744
Extracellular vesicles (EVs) are small membranous vesicles that contain an abundant cargo of different RNA species with specialized functions and clinical implications. Here, we introduce an updated online database (http://www.exoRBase.org), exoRBase 2.0, which is a repository of EV long RNAs (termed exLRs) derived from RNA-seq data analyses of diverse human body fluids. In exoRBase 2.0, the number of exLRs has increased to 19 643 messenger RNAs (mRNAs), 15 645 long non-coding RNAs (lncRNAs) and 79 084 circular RNAs (circRNAs) obtained from ∼1000 human blood, urine, cerebrospinal fluid (CSF) and bile samples. Importantly, exoRBase 2.0 not only integrates and compares exLR expression profiles but also visualizes the pathway-level functional changes and the heterogeneity of origins of circulating EVs in the context of different physiological and pathological conditions. Our database provides an attractive platform for the identification of novel exLR signatures from human biofluids that will aid in the discovery of new circulating biomarkers to improve disease diagnosis and therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Bases de Datos Genéticas / ARN Largo no Codificante / ARN Circular Límite: Humans Idioma: En Revista: Nucleic Acids Res Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Bases de Datos Genéticas / ARN Largo no Codificante / ARN Circular Límite: Humans Idioma: En Revista: Nucleic Acids Res Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido