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Intermediate progenitor cells provide a transition between hematopoietic progenitors and their differentiated descendants.
Spratford, Carrie M; Goins, Lauren M; Chi, Fangtao; Girard, Juliet R; Macias, Savannah N; Ho, Vivien W; Banerjee, Utpal.
Afiliación
  • Spratford CM; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, USA.
  • Goins LM; Molecular Biology Institute, University of California, Los Angeles, USA.
  • Chi F; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, USA.
  • Girard JR; Molecular Biology Institute, University of California, Los Angeles, USA.
  • Macias SN; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, USA.
  • Ho VW; Molecular Biology Institute, University of California, Los Angeles, USA.
  • Banerjee U; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, USA.
Development ; 148(24)2021 12 15.
Article en En | MEDLINE | ID: mdl-34918741
Genetic and genomic analysis in Drosophila suggests that hematopoietic progenitors likely transition into terminal fates via intermediate progenitors (IPs) with some characteristics of either, but perhaps maintaining IP-specific markers. In the past, IPs have not been directly visualized and investigated owing to lack of appropriate genetic tools. Here, we report a Split GAL4 construct, CHIZ-GAL4, that identifies IPs as cells physically juxtaposed between true progenitors and differentiating hemocytes. IPs are a distinct cell type with a unique cell-cycle profile and they remain multipotent for all blood cell fates. In addition, through their dynamic control of the Notch ligand Serrate, IPs specify the fate of direct neighbors. The Ras pathway controls the number of IP cells and promotes their transition into differentiating cells. This study suggests that it would be useful to characterize such intermediate populations of cells in mammalian hematopoietic systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas de Drosophila / Receptores Notch / Proteína Jagged-1 / Hematopoyesis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas de Drosophila / Receptores Notch / Proteína Jagged-1 / Hematopoyesis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido