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Nutritional Ketosis as a Potential Treatment for Alcohol Use Disorder.
Mahajan, Vikrant R; Elvig, Sophie K; Vendruscolo, Leandro F; Koob, George F; Darcey, Valerie L; King, M Todd; Kranzler, Henry R; Volkow, Nora D; Wiers, Corinde E.
Afiliación
  • Mahajan VR; Department of Pharmacology, Vanderbilt University, Nashville, TN, United States.
  • Elvig SK; Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Baltimore, MD, United States.
  • Vendruscolo LF; Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Baltimore, MD, United States.
  • Koob GF; Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Baltimore, MD, United States.
  • Darcey VL; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States.
  • King MT; National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, United States.
  • Kranzler HR; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
  • Volkow ND; National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, United States.
  • Wiers CE; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Front Psychiatry ; 12: 781668, 2021.
Article en En | MEDLINE | ID: mdl-34916977
Alcohol use disorder (AUD) is a chronic, relapsing brain disorder, characterized by compulsive alcohol seeking and disrupted brain function. In individuals with AUD, abstinence from alcohol often precipitates withdrawal symptoms than can be life threatening. Here, we review evidence for nutritional ketosis as a potential means to reduce withdrawal and alcohol craving. We also review the underlying mechanisms of action of ketosis. Several findings suggest that during alcohol intoxication there is a shift from glucose to acetate metabolism that is enhanced in individuals with AUD. During withdrawal, there is a decline in acetate levels that can result in an energy deficit and could contribute to neurotoxicity. A ketogenic diet or ingestion of a ketone ester elevates ketone bodies (acetoacetate, ß-hydroxybutyrate and acetone) in plasma and brain, resulting in nutritional ketosis. These effects have been shown to reduce alcohol withdrawal symptoms, alcohol craving, and alcohol consumption in both preclinical and clinical studies. Thus, nutritional ketosis may represent a unique treatment option for AUD: namely, a nutritional intervention that could be used alone or to augment the effects of medications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza