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Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Mamais, Adamantios; Kluss, Jillian H; Bonet-Ponce, Luis; Landeck, Natalie; Langston, Rebekah G; Smith, Nathan; Beilina, Alexandra; Kaganovich, Alice; Ghosh, Manik C; Pellegrini, Laura; Kumaran, Ravindran; Papazoglou, Ioannis; Heaton, George R; Bandopadhyay, Rina; Maio, Nunziata; Kim, Changyoun; LaVoie, Matthew J; Gershlick, David C; Cookson, Mark R.
Afiliación
  • Mamais A; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
  • Kluss JH; Department of Neurology, University of Florida, Gainesville, Florida, United States of America.
  • Bonet-Ponce L; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
  • Landeck N; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
  • Langston RG; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
  • Smith N; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
  • Beilina A; Department of Biochemistry and the Redox Biology Center, University of Nebraska, Lincoln, Nebraska, United States of America.
  • Kaganovich A; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
  • Ghosh MC; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
  • Pellegrini L; Molecular Medicine Branch, 'Eunice Kennedy Shriver' National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America.
  • Kumaran R; MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
  • Papazoglou I; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
  • Heaton GR; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Bandopadhyay R; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
  • Maio N; UCL Institute of Neurology and Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom.
  • Kim C; Molecular Medicine Branch, 'Eunice Kennedy Shriver' National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America.
  • LaVoie MJ; Molecular Neuropathology Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
  • Gershlick DC; Department of Neurology, University of Florida, Gainesville, Florida, United States of America.
  • Cookson MR; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
PLoS Biol ; 19(12): e3001480, 2021 12.
Article en En | MEDLINE | ID: mdl-34914695
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Unión al GTP rab / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Límite: Aged / Animals / Humans / Male / Middle aged Idioma: En Revista: PLoS Biol Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Unión al GTP rab / Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina Límite: Aged / Animals / Humans / Male / Middle aged Idioma: En Revista: PLoS Biol Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos